Protein folding problem solved?

murphy kenneth p kpmurphy at blue.weeg.uiowa.edu
Sat Jun 10 10:30:58 EST 1995


In article <3rcbb4$cee at lyra.csx.cam.ac.uk>,
Simon Brocklehurst (Bioc) <smb18 at mole.bio.cam.ac.uk> wrote:
>rvenable at deimos.cber.nih.gov (Rick Venable) writes:
>
>> Given that the crystal is a somewhat artificial environment,
>
>  Sorry, can't let you get away with saying that - too many people 
>will believe what you're saying.  Crystal structures of proteins are,
>for the most part, excellent models for the structure in solution.
>_________________________________________________________________________
>|
>|  ,_ o     Simon M. Brocklehurst,
>| /  //\,   Oxford Centre for Molecular Sciences
>|   \>> |   Department of Biochemistry, University of Oxford,
>|    \\,    Oxford, UK.
>|           E-mail: smb at bioch.ox.ac.uk
>|________________________________________________________________________
>
>

To which one might add that proteins in crystals practically *are* in solution
since the percentage solvent is so high.

Regards,
Kip

--
Dr. Kenneth P. Murphy				e-mail: k-murphy at uiowa.edu
Department of Biochemistry			office: (319)335-8910
University of Iowa				lab:  (319)335-7936
Iowa City, IA 52242            		        FAX:  (319)335-9570



More information about the Molmodel mailing list