Protein folding problem solved?
Simon Brocklehurst Bioc
smb18 at mole.bio.cam.ac.uk
Mon Jun 12 06:04:20 EST 1995
rvenable at deimos.cber.nih.gov (Rick Venable) writes:
>On 11 Jun 1995 14:41:15 GMT Simon Brocklehurst (Bioc) pontificated:
Ha ha ha.
>> The take-home message to be drawn from comparisons NMR and X-ray
>> structures is that they're pretty much the same for all parts of the
>> protein, not just the core.
>While that is *generally* true, I suggest that there have been enough
>exceptions to advise a little skepticism, and not dogmatically accept
>as gospel the notion that a given crystal structure represents the dominant
Can't most examples of differences in loop structure between NMR and X-ray
structures be trivially attributed to crystal contacts? This isn't
big news. It isn't particularly helpful to suggest that, because of this problem,
people should be sceptical about all parts of X-ray structures that aren't part of
| ,_ o Simon M. Brocklehurst,
| / //\, Oxford Centre for Molecular Sciences, Department of Biochemistry,
| \>> | University of Oxford, Oxford, UK.
| \\, E-mail: smb at bioch.ox.ac.uk | WWW: http://www.ocms.ox.ac.uk/~smb/
More information about the Molmodel