Naming of phosphate oxygens in nucleotides
slickers at imb-jena.de
Mon Nov 20 03:58:18 EST 1995
Deoxy-nucleotides have three prochiral centers -- C2', C5', and P.
This prochiral centers are carrying two identical substituents but
although it is possible to assign unambigously a unique name to
each substituent. This is done in IUPAC recommendations of 1982
(1983. Europ J Biochem, 131: 9-15.) for H2'1, H2'2 of C2' and
H5'1, H5'2 of C5'. H2'1 and H5'1 are pro-S whereas H2'2 and H5'2 are
DOES anybody knows if there is any recommendation for the naming of the
two phosphate oxygens OP1 and OP2 according to their position in
relation to the central P ?
The structural meaning of this would be, whether OP1 is pointing towards
the minor or the major groove in a DNA double helix.
Peter Slickers slickers at imb-jena.de
Institut fuer Molekulare Biotechnologie
Beutenbergstrasse 11, Jena Tel.: +49-3641-65-6202
Postfach 10 08 13, D-07708 Jena, Germany Fax: +49-3641-65-6210
More information about the Molmodel