DNA model building

varied fedorov at uwchem.chem.washington.edu
Sun Sep 1 07:41:14 EST 1996


In article <Pine.SOL.3.91.960901004033.12370A-100000 at gate>,
wstzou at GATE.SINICA.EDU.TW (Wen-shyong Tzou) wrote:

> Hi:
>         To summarize the responses of the questions about the  methods to 
> measure the nucleic acid parameters and/or construct a new nucleic acid 
> from scratch based on a new set of parameters, it follows:
> 
> 1) BIOSYM/MSI InsightII  and MacroModel for DNA.
> 2) MC-SYM (http://www.iro.umontreal.ca/people/major/mcsym.html) for RNA
> 3) NAB for DNA (http://scripps.edu/case)
> 4) newhel93 for DNA available in PDB (http://www.gdb.org/hopkins.html)
> 5) Rasmol (http://www.gdb.org/hopkins.html)
> 

IMHO, the most consistent and flexible set of DNA modeling software is
CURVES/JUMNA, developed by Sklenar and Lavery. You can easily manipulete 
all structural parameters and build curved DNA, stem-loops, triplexes,
drug-DNA complexes and so on.

Cheers, Oleg Fedoroff, Ph.D.



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