homology modelling

Michel PETITJEAN ptitjean at ccr.jussieu.fr
Thu Mar 6 07:58:40 EST 1997


In article <5fm049$o3 at rc1.vub.ac.be>,
ldewit at ben.vub.ac.be (Dimitri Harmegnies) wrote:

>Does anybody could explain me the principle of homology modelling (for
>example, wich percent of sequence homology is considered as sufficient
>to suppose a structural homology ?)

100% do not suffice. The same protein (100% sequence homology) may
offer various conformations with poor 3D-structural homology.
I do not know if the reverse exists or not: high percentage of 3D
homology but low percentage of sequence homology.

Michel Petitjean,                     Email: petitjean at itodys.jussieu.fr
ITODYS (CNRS, URA34)                         ptitjean at ccr.jussieu.fr



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