PhD positions available

Alexandre M.J.J. Bonvin abonvin at
Wed Jun 2 04:18:59 EST 1999

Graduate student positions available

Three graduate student positions are available within the NMR spectroscopy 
department of the Bijvoet Center for Biomolecular Research at Utrecht

The research of the Utrecht NMR group deals with problems in biochemistry and 
molecular biology studied by the method of high-resolution NMR spectroscopy. 
The group also contributes to the development of NMR methodology. A major theme 
is that of the regulation of gene expression with aspects of both protein-
nucleic acid interaction and protein-protein interaction. These interactions 
are studied in bacterial repressors, eukaryotic transcription factors and
initiation factors involved in protein biosynthesis. The aim is to understand
these biomolecular recognition processes in terms of detailed three-dimensional
structures and dynamics. With respect to NMR methodology, novel NMR experiments
and methods for structure refinement and for the quality assessment of protein 
NMR structures are being developed in the group. 

The NMR infrastructure at the Bijvoet Center is excellent with NMR spectrometers 
covering the range from 300 to 750 MHz (funding for a 900 MHz spectrometer has 
been approved) and state of the art computers and laboratory facilities for 
cloning and protein expression.

The Ph.D. positions are for a period of four years. Possible research projects 

- NMR structural studies of DNA-binding repair enzymes
- development and application of fast protocols for NMR structure determination 
  toward structure-based functional genomics
- Protein-DNA interaction of retinoic acids receptors

For additional information contact:
	Prof. Dr. R. Kaptein	kaptein at
	Prof. Dr. R. Boelens	boelens at
	Dr. A.M.J.J. Bonvin	abonvin at

Contact address:
	Bijvoet Center for Biomolecular Research 
	Department of NMR Spectroscopy
	Padualaan 8, 3584 CH Utrecht, the Netherlands
	Phone: +31-30-2532652, fax: +31-30-2537623

| Dr. Alexandre Bonvin         | Phone: Int+31-30-2533859            |
| NMR, Utrecht University      | Fax:   Int+31-30-2537623            |
| Padualaan 8, 3584 CH Utrecht | Email: abonvin at       |
| The Netherlands              |  | 

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