close 5' ends

Matthew Sachs msachs at ADMIN.OGI.EDU
Thu Apr 28 15:37:51 EST 1994


>   We have recently mapped the 5' ends of two linked genes which are both
>involved in HC-toxin production in Cochliobolus carbonum.  These genes are
>transcribed from opposite DNA strands, and are only 412 bp apart.  Given the
>"average" size of filamentous fungal promoters, these genes are remarkably
>close together.  Does anyone know of other such close genes/promoters?  The
>only other example I know of is the qa cluster of N. crassa, and I think the
>closest genes in this cluster are c. 1 kb apart.
>
>
>  Thank you
>John Pitkin
>MSU-DOE Plant Research Laboratory
>Michigan State University
>e-mail: JPITKIN at MSU.EDU

See:

Chow, CM and RajBhandary, UL (1993) Developmental regulation of the gene
for formate dehydrogenase in Neurospora crassa. J. Bacteriol. 175:
3703-3709. 

fdh and leu-5 are transcribed from opposite strands; they are approximately
0.6 kb apart.


-----------------------------------------------------------
Matthew Sachs
Department of Chemistry, Biochemistry and Molecular Biology
Oregon Graduate Institute of Science and Technology
20000 NW Walker Road
P.O. Box 91000
Portland, OR  97291-1000
503 690-1487 Phone
503 690-1464 Fax
msachs at admin.ogi.edu




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