Post doc in Molecular Mycology
MICRB at leeds.ac.uk
Fri Jul 11 07:43:49 EST 1997
THE UNIVERSITY OF LEEDS
DEPARTMENT OF MICROBIOLOGY
APPOINTMENT OF A POSTDOCTORAL RESEARCH FELLOW
IN MOLECULAR MYCOLOGY
A Postdoctoral Research Fellow is required for a 2-year project
on the Molecular Strain Typing of Dermatophyte Fungi. The aim is to
develop probes for fungal strain differentiation which enable more
accurate investigations of the epidemiology of dermatophyte infections.
Dermatophytes cause a variety of superficial infections of
skin, nail and hair which are usually easily treated. However, in
certain cases, particularly nail infections caused by Trichophyton
rubrum and T.mentagrophytes, infections are more intractable and
infection often recurs following cessation of therapy. In these cases,
in order to determine whether the recurrence is due to relapse of the
original infection or reinfection with a new strain, it is necessary to
develop tools to distinguish between different isolates of these fungi.
The most sensitive methods of distinguishing between strains of many
fungal species involve some form of genotyping, exploiting differences
in the DNA of different strains.
There is a major interest in Medical Mycology in the Department
of Microbiology and the PHLS Mycology Reference Laboratory is located
in the Department - this is a national reference laboratory for the
diagnosis and treatment of fungal infections and therefore there is
ready access to the clinical isolates required for this study.
We propose to isolate sequences from T.rubrum and
T.mentagrophytes which would be useful as probes for the
differentiation of strains of these fungi. These probes will then be
used to examine the epidemiology of dermatophyte infections caused by
these fungi, particularly recurrent nail infections.
Postdoctoral Research Fellow
The person appointed will have a PhD and a background in
molecular biology, preferably with experience in genomic library
construction and molecular cloning. This experience would ideally be
with fungi but applicants who have worked with bacteria or other
microorganisms are also encouraged to apply.
Salary will be on the Grade IA scale, £15,159 - £17,606, with
participation in the USS superannuation scheme. The project is
sponsored by the Janssen Research Foundation, a Division of Janssen
Pharmaceutica, Belgium and is for 2 years. The proposed starting date
is 1st September 1997 or as soon as possible after this date.
Applications should include a curriculum vitae, with the names
of three referees and a covering letter and should be sent to Professor
E G V Evans, Department of Microbiology, University of Leeds, Leeds,
LS2 9JT to arrive no later than 15th August 1997.
Informal enquiries may be made to Professor E G V Evans, Tel:
0113 233 5590 or Dr R Barton, Tel: 0113 233 5598.
THE UNIVERSITY OF LEEDS PROMOTES AN EQUAL OPPORTUNITIES POLICY
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