New ProtComp (V4): Program for Identification of protein sub-cellular localization

webmaster webmaster at softberry.com
Mon Jan 29 09:56:05 EST 2001


ProtComp - Version 4: Program for Identification of sub-cellular localization  
         of Eukaryotic proteins: Animal/Fungi  - Plants  
 
NEW   ProtComp is available for public usage at: http://www.softberry.com/  
 
         http://www.softberry.com/protein.html  
 
   ProtComp:  Current, fourth release of ProtComp developed using 
COMBINATION of database analysis of similar proteins and NEURAL NET 
recognizers separately trained for Animal/Fungi and Plant proteins.  
 This separation is improving the recognition accuracy, which is  
   for major compartments (such as plasma membrane, nuclear,  
   extracellular) achives >90% level.  
 
            The program initially searches our database of proteins 
with known sub-cellular location and defines the location the same as 
for protein having significant similarity. If such similarity is 
absent we use complex neural-network recognizers, which identify 
probability of the subcellular localization in nucleus, plasma 
membrane, extracellular, cytoplasmic, mitochondrial, chloroplast, 
endoplasmic reticulum, peroxisomal, lysosomal or Golgi compartments.  
 
      Example of Output results:  
     Presents scores for Similar protein, different networks and the final 
conclusion.  
protcompan  Mon Jan 29 02:38:30 EST 2001
ProtComp Version 3. Identifying sub-cellular location (Animals&Fungi)
Seq name: P426
Significant similarity by DBSCAN-P -  Location:Cytoplasmic  S=12980
Predicted by Neural Nets - Cytoplasmic with score    1.7
Integral Prediction of protein location: Cytoplasmic with score    2.6
Location weights: DBSCAN-P / Neural Nets / Integral
 Nuclear             554.0 /        1.18 /     0.11
 Plasma membrane       0.0 /        0.98 /     0.00
 Extracellular         0.0 /        0.76 /     0.00
 Cytoplasmic       12980.0 /        1.67 /     2.60
 Mitochondrial         0.0 /        0.73 /     0.00
 Endoplasm. retic.     0.0 /        0.62 /     0.00
 Peroxisomal           0.0 /        0.67 /     0.00
 Lysosomal             0.0 /        0.27 /     0.00
 Golgi                 0.0 /        0.83 /     0.00


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