Neurotransmitters in C. elegans

Sean Eddy eddy at boulder.Colorado.EDU
Thu Dec 17 09:28:19 EST 1992


khofmann at biomed.biolan.uni-koeln.de writes:
> Can anybody tell me, what kind of neurotransmitters are used in the worm
>Caenorhabditis elegans? This species has to my knowledge (but I am no
>neuroscientist) a small but fairly developed nervous system. But I was not
>able to track down any information on the neurotransmitters used in 
>C.elegans synapses.

A good starting reference would be M. Chalfie and J. White's
chapter in _The Nematode Caenorhabditis elegans_, W.B. Wood (ed.), 
1988, Cold Spring Harbor Laboratory Press.

It's thought that excitatory body-wall muscle motor neurons
use acetylcholine. Inhibitory motor neurons use GABA. 

Excitatory motor neurons in the egg-laying circuitry seem
to be using serotonin.

Dopamine and octopamine have been detected in the worm as
well.

- Sean Eddy
- MRC Laboratory of Molecular Biology
- sre at mrc-lmb.cam.ac.uk



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