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microtubule elongation

mark at uucp.nibr mark at uucp.nibr
Thu Jul 23 02:44:18 EST 1992

I am working on a model concerning the elongation of microtubules
in neurons during outgrowth. My model so far shows that stopping
neuritic outgrowth by stopping microtubule outgrowth demands a stop
of the input of material in the outgrowing neuritic tips. I have two
questions about this, which I could not trace out in literature:

1 - Is elevated calcium able to (locally) block transport of soluble
    proteins at the site of the growth cone ?

2 - Is the production of tubulin (all isoforms) at the soma regulated
    by the concentration of tubulin ? More specifically: is there a
    negative feedback system ?

All responses would be welcome,

Mark van Veen
Neth. Inst. Brain Research
mark%nibr at nluug.nl

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