mechanism of barbiturate anesthesia

Kurt Franklin Ahrens kurt at
Thu Aug 19 19:10:02 EST 1993

In our lab, when we perform chronic electrode placement surgery on
rats, we use sodium pentobarbital (Nembutal) as the anesthetic.  My
question is by what mechanism(s) does this chemical act?  I would like
references on its effects on the neuronal membrane, signal propagation, 
and synaptic transmission.  Thanks in advance.  

Kurt F. Ahrens (kurt at
Division of Neurobiology in the Department of Molecular and Cell Biology
UC Berkeley

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