Acetylcholinesterase-Alzheimers Question?????

Andrew Penn andrew at uaneuro.uah.ualberta.ca
Thu Jan 7 19:55:23 EST 1993


In article <1993Jan6.180218.9721 at welchgate.welch.jhu.edu>  
danj at welchgate.welch.jhu.edu (Dan Jacobson) writes:
> pmuniyap at magnus.acs.ohio-state.edu writes:
> 
> >     Is there any evidence to support that the neuro-enzyme
> >Acetylcholinesterase (AChE) is associated with any diseases?  For eg,
> >Alzheimers Disease.  I have just started a research project involving  
AChE and
> >I am curious of the potential for continued research in this area.
> 
> This is a good question to ask the database known as ONLINE MENDELIAN 
> INHERITANCE IN MAN (OMIM).  There are several ways that you can access
> this database.  Probably the easiest is by Gopher or Wais.  If you have
> gopher, point it at merlot.welch.jhu.edu (port 70).  Go to the
> 
> 13. Search Databases at Welchlab (Cloning Vectors, Euk. Promoters,  
NRL_3D, OMIM)
> 
> directory and select the following search - 
> 
>  -->  5.  OMIM - Online Mendelian Inheritance Man <?>
> 
> A search with the word Acetylcholinesterase returns the following  
entries:
> 
>  -->  1.  *100740 ACETYLCHOLINESTERASE [ACETYLCHOLINE ACETYLHYDROLASE;  
ACHE].
>       2.  100680 ACETYLCHOLINESTERASE EXPRESSION [ACEE; REGULATOR  
OFACETYLC.
>       3.  254190 MYASTHENIA, CONGENITAL, REFRACTORY TO  
ACETYLCHOLINESTERASE.
>       4.  #112100 BLOOD GROUP--Yt SYSTEM [YT; CARTWRIGHT].
>       5.  *177400 PSEUDOCHOLINESTERASE, E(1) [CHE1;  
BUTYRYLCHOLINESTERASE;B.
>       6.  *254210 MYASTHENIA GRAVIS, FAMILIAL INFANTILE [FIMG;  
MYASTHENIA,C.
>       7.  *114836 CARBOXYLESTERASE, LIVER.
>       8.  *118503 CHOLINERGIC RECEPTOR, NEURONAL NICOTINIC, ALPHA  
POLYPEPTI.
>       9.  *178630 PULMONARY SURFACTANT APOPROTEIN PSP-A [PSAP;  
SURFACTANT-A.
> 
> Now you can select the desired entries, read them and save them on your  
machine
> if you'd like.
> 
> If you'd rather connect by Wais the source is as follows:
> 
> (:source
>    :version  3
>    :ip-address "128.220.59.10"
>    :ip-name "welchlab.welch.jhu.edu"
>    :tcp-port 210
>    :database-name "omim"
>    :cost 0.00
>    :cost-unit :free
>    :maintainer "francois at welch.jhu.edu"
>    :subjects "science genetics medicine chromosomes biology mendelian"
> )
> 
> 
> 
> Best of luck,
> 
> Dan Jacobson
> 
> danj at welchgate.welch.jhu.edu


Most of these references refer to AChesterase in the peripheral nervous  
system, not the CNS.

Andrew Penn



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