PC-12 Cells

Duke Groebe drg at prophet.pharm.pitt.edu
Mon Oct 11 11:32:22 EST 1993


In article <299neq$cme at charm.magnus.acs.ohio-state.edu>,
misandst at magnus.acs.ohio-state.edu (Michael I Sandstrom) wrote:
> 
> 
>      I am looking for references regarding the PC-12 cell line.  What
> is the history of this line?  Where did these cells come from?  What does
> in-vitro electrophysiology et cetera really tell us about the neuron
> of the CNS?  Is this cell line capable of much differentiation?  Someone
> please direct me to the appropriate literature (review papers etc.).
> Thanks in advance!
> 

The PC-12 cell line was established by L. Greene and A. Tischler (PNAS vol.
73, p. 2424-2426, 1976) from a transplantable rat adrenal pheochomocytoma. 
Induction of a neuronal phenotype occurs using nerve growth factor (NGF). 
These cells have been extesively used in the study of cellular development
and regulation of gene expression.  If you have access to Medline, search
under the keyword "PC-12".  You ought to get hundreds of literature
references.
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