Seeking Postdoctoral Position

Jianguo Gu jgu at ccu.umanitoba.ca
Thu Sep 16 14:02:09 EST 1993


Hi, My name is Jianguo Gu and I am anticipating on completing all
requirements for the Ph.D. degree in the Department of Pharmacology and
Therapeutics at the University of Manitoba in Winnipeg,Canada by February
of 1994. I have been trained in the areas of cardiovascular pharmacology, 
pharmacokinetics, neuropharmacology, neurochemistry, and neuroanatomy, with
an emphasis on techniques such as characterization of membrane transport
system for neurotransmitter release and uptake, determination of
intracellular Ca2+ mobilization, receptor binding assay, enzyme assay,
radioimmunoassay, cell culture, bioluminescence assay, HPLC, TLC, and
surgical procedures. I am actively seeking a postdoctoral training position
in research areas relating to purine and EAA actions in the CNS, mechanism
of neuronal degeneration, calcium homeostasis, or other areas relating to
my background. If you are interested in me please feel free to contact me. 

Sincerely yours,

Jianguo Gu
Phone: (204)789-3454
Fax: (204)783-6915
E-mail: Jgu at cc.umanitoba.ca


			

			CURRICULUM VITAE


BIOGRAPHICAL NOTES

NAME:	Jianguo Gu

ADDRESS: Department of Pharmacology and Therapeutics, University of
	 Manitoba Faculty of Medicine, 770 Bannatyne Ave., Winnipeg, Manitoba,
	 Canada, R3E 0W3

PHONE:	(204) 772-3814 (H)
	(204) 788-6454 (W)
 
DATE OF BIRTH:	June 16, 1961

PLACE OF BIRTH:	Nanjing, Jiangsu, China

CITIZENSHIP:	China (Landed Immigrant in Canada Since March, 1991)



I	Academic Training

	1989 - Present	Ph.D.	Department of Pharmacology and Therapeutics
				University of Manitoba
				Winnipeg, Manitoba, Canada
				Supervisor:  Dr. J.D. Geiger

	1984 - 1987	M.Sc.	Department of Pharmacology
				Nanjing Pharmaceutical University
				Nanjing, China

	1979 - 1984	M.B.	Shanghai Medical University
				Shanghai, China

II	Positions Held

	1987 - 1989		Teaching and Research Associate
				Department of Pharmacology
				Nanjing Pharmaceutical University

III	Affiliations

	1991 - present		Society for Neuroscience

IV	Awards

	1979-1984	Shanghai Medical University Studentship
	1988		The 2nd prize of Chinese National Health Science 
			Research Award
	1989		Jiangsu Provincial Award for Basic Medical Science
		 	Research
	1989-1990	Studentship of the Department Pharmacology at 
			University of Manitoba
	1991		University of  Manitoba Fellowship (declined)
	1991-1993	Manitoba Health Research Council Studentship 
	1993-present	Medical Research Council of Canada Studentship
	1993		University of Manitoba travel fellowship

V	Research Experience and Techniques 

	I have been trained in the areas of cardiovascular pharmacology,
pharmacokinetics, neuropharmacology, neurochemistry, and neuroanatomy,
with an emphasis on techniques such as characterization of membrane
transport system for neurotransmitter release and uptake, determination of
intracellular Ca2+ mobilization, receptor binding assay, enzyme assay,
radioimmunoassay, cell culture, bioluminescence assay, HPLC, TLC, and
surgical procedures. 

1983 - 1984       I studied the effects of cardiovascular agents on the levels
of cAMP and prostaglandins in dog hearts and blood vessels.

1984 - 1987       I studied the mechanisms by which cardiac sudden death was
induced by abruptwithdrawal of propranolol. I determined the effects of
propranolol withdrawal on cardiac rhythm and on the levels of cAMP, CPK,
adenine nucleotides, and catecholamines in dog hearts with coronary artery
ligation. Furthermore, I measured the effects of propranolol on adrenergic
receptor density in rat and dog hearts.

1989 - present    Following enrollment in the Ph.D. program in the Department
of Pharmacology	at the University of Manitoba I conducted 4 months of research
in the laboratory of Dr. R. Man as part of a Departmental course (students
must do two 4 month rotations in different laboratories). There I measured
phospholipids in heart tissues following ischemic insults.

     My second rotation was with Dr. J.D. Geiger who is now my
supervisor. My projects here have been to determine the transport
characteristics of the metabolically stable enantiomeric probe L-adenosine,
to determine the extent to which metabolism of physiological D-adenosine
affects the kinetics of D-adenosine transport in rat brain and to determine
adenosine transport in postmortem human brain and cultured human fetal
brain cells. 

     My projects have also been extended to the determination of
endogenous diadenosine polyphosphates in rat brain by HPLC coupled with
bioluminescence assay, the role of diadenosine polyphosphates on
intracellular Ca2+ mobilization, on nitric oxide synthesis, and on cGMP
production induced by sodium nitroprusside.


PUBLICATIONS

Papers published

1. Zhu, L., Ling, D.L., Gu, C.L., Li, Y.H., Gu, J.G., Shao, Y.D., Wang,
J.Y., and Li, Z. (1986) Effects of an aqueous extract of sargentodoxa
cuneata on platelet aggregation, coronary flow, thrombus formation, and
plasma and platelet cAMP levels. Acta Academia Medicinae Shanghai 13,
346-350. 

2. Gu, J.G. and Wang, L.Y. (1987) Roles of calcium blockers in the
treatment of hypertensive diseases.  Progress in Pharmaceutical Sciences
11, 58-61. 

3. Dai, D.Z., Ron, P., Shi, Z.J., Wang, L.Y., Dai, Y., Huang, J., and Gu,
J.G. ( 1987) Noradrenaline depletion following myocardial infarction in
rat and dog hearts. Chinese Journal of Physiological Science 3, 429-432. 

4. Dai, D.Z. and Gu, J.G. (1987) Kinetic effects of propranolol and its
counterclockwise hysteresis loop. in Mechanism of sudden cardiac death in
patients who take propranolol for long term and stop it abruptly. D.Z.
Dai, ed. (Nanjing: Nanyu), pp.22-28

5. Gu, J.G. (1988) Application of ligand binding assay to development of
new calcium antagonists and activators. Studies of Pharmacology 6, 38-41

6. Zhu, L., Shao, Y.D., Wang, J.Y., Lin, D.L., Gu, C.L., Li, Y.H., Gu,
J.G., Dai, H.J., Dong, J.C. and Xue, F. (1988) Effects of beta-phenyl
acetic acid on platelet aggregation, thrombosis formation, and plasma cAMP
content. Acta Pharmacologica Sinica 9, 249-251. 

7. Gu, J.G., Ron, P., Wang, L.Y., Dai, D.Z. (1989) Determination of ATP,
ADP, and AMP levels in rat myocardium after ligation of coronary artery. 
Journal of China Pharmaceutical University 20, 103-105. 

8. Gu, J.G., Delaney, S., Sawka, A.S., and Geiger, J.D. (1991)
[3H]L-Adenosine, a new metabolic stable enantiomeric probe for adenosine
transport systems in rat brain synaptoneurosomes. Journal of
Neurochemistry 56, 548-552. 

9. Gu, J.G. and Geiger, J.D. (1992) Transport and metabolism of
[3H]D-adenosine and [3H]L- adenosine in rat brain synaptoneurosomes.
Journal of Neurochemistry 58, 1699-1705. 

10. Gu, J.G., Kala, G., and Geiger, J.D. (1993) [3H]Adenosine transport in
synaptoneurosomes of postmortem human brain. Journal of Neurochemistry 60,
2232-2237

Papers submitted

1. Gu, J.G. and Geiger, J.D. Effects of diadenosine polyphosphates on
soluble guanylate cyclase activity induced by sodium nitroprusside in rat
cerebellum. Journal of Neurochemistry

2. Chen, Q.-M., Smyth, D.D., McKenzie, J.K., Glavin, G.B., Gu, J.G.,
Geiger, J.D., and LaBella, F.S.  Chloro-tyrosine exerts renal effects and
antagonizes renal and gastric responses to atrial natriuretic peptide. 
Journal of Pharmacology and Experimental Therapeutics

Papers in preparation

1. Gu, J.G. and Geiger, J.D.  Kinetics and pharmacology of adenosine
transport in cultured fetal human brain astrocytes. 

2. Gu, J.G. and Geiger, J.D.  Effects of diadenosine polyphosphates on
Ca2+ mobilization in synaptosomes prepared from rat cerebral cortex. 

Abstracts 

1. Dai, D.Z., Gu, J.G., Lu, H.H., Ma, J.J., and Sheng, L.S. (1988)
Determination of rabbit plasma concentrations and pharmacokinetic
parameters of MI2, a new potent antiarrhythmic indole derivative by HPLC.
Information of the Chinese Pharmacological Society 5, 40. 

2. Dai, D.Z., Gu, J.G. and Chui, Y.R. (1988) Determination of the plasma
concentrations and pharmacokinetic parameters of some indole derivatives
in rabbits by thin layer chromatography.  Information of the Chinese
Pharmacological Society 5, 41. 

3. Gu, J.G., Dai, D.Z., and Rong, P. (1988) Determination of ATP, ADP, and
AMP in myocardium by HPLC.  Information of the Chinese Pharmacological
Society 5, 17. 

4. Wang, F.P., Gu, J.G., and Dai, D.Z. (1988) Effects of 7 nitrobenzyl
berberines on cardiovascular system. 5th Southeast Asian and Western
Pacific Regional Meeting of Pharmacology R40, 10. 

5. Gu, J.G., Rong, P., and Dai, D.Z. (1988) Depletion of noradrenaline and
ATP at non-infarcted zone following acute myocardial infarction in rats.
5th Southeast Asian and Western Pacific Regional Meeting of Pharmacology
S13, 10. 

6. Gu, J.G., Rong, P., and Dai, D.Z. (1988) Prevention of noradrenaline
and ATP depletion at infarcted and non-infarcted zone of rat hearts by
propranolol and verapamil. 5th Southeast Asian and Western Pacific
Regional Meeting of Pharmacology, S13, 29. 

7. Rong, P., Gu, J.G., and Dai, D.Z. (1989) Global biochemical responses
induced by myocardial infarction. Jiangsu and Hong Kong Pharmacological
Meeting 1, 58. 

8. Gu, J.G. and Geiger, J.D. (1991) Transport kinetics and metabolism of
accumulated [3H]D- adenosine and [3H]L-adenosine in rat brain
synaptoneurosomes. 21th Annual Meeting 


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