Neurobiology of Fear

an102766 at an102766 at
Fri Dec 16 00:26:22 EST 1994

mwspitze at (matt spitzer) wrote:

>Fair enough.  Just out of curiosity, are there any candidates for an
>endogenous ligand that might act at the benzodiazepine site to regulate the
>GABA receptor?

In the book "Panic Anxiety and its Treatments", edited by G.L. Klerman,
etc., under the subheading "Abnormal endogenous ligand therory", the
authors give the following references:

Barbaccia MC, Coste E, Ferrero P, et al: Diazepam binding inhibitor.
Arch Gen Psychiatry 43:1143-1147, 1985

Britton KT, Page M, Baldwin H, et al: Anxiolytic activity of steroid
anesthetic alphaxalone. J Pharmacol Exp Ther 258(1):124-129, 1991.
Identify the naturally occurring pregnane steroids 
3 alpha, 5 alpha-tetrahydroxycorticosterone and 
3 alpha-hydroxy 5 alpha-dihydroprogesterone.

Hope this helps,

To find out more about the anon service, send mail to help at
Due to the double-blind, any mail replies to this message will be anonymized,
and an anonymous id will be allocated automatically. You have been warned.
Please report any problems, inappropriate use etc. to admin at

More information about the Neur-sci mailing list