cell line

Mark Mattson mpm at seqanal.mi.uky.edu
Thu Jan 27 10:19:50 EST 1994


Patrick Doyle (pdoyle at medsun.unige.ch) wrote:
: After considering starting cell culture of astrocytes does anyone have any
: comments as to the usefulness of bought cell lines such as the c6 glioma
: line?
: In particular how "normal" are these cells metabolically? Pat.

C6 cells are extremely abnormal.  As transformed (i.e., tumor) cells, they
are considerably altered in growth properties, regulation of calcium, etc.
However, many people use them and you may be able to use them initially for
pilot studies.  But if you want to know something about astrocytes, USE
ASTROCYTES; they're really quite easy to establish and grow.

Best of luck,
Steven W. Barger, Ph.D.
Sanders-Brown Center on Agin



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