Realistic Neuronal Models
HARRY R. ERWIN
herwin at mason1.gmu.edu
Thu Jul 28 21:03:41 EST 1994
I just finished Bartlett Mel (1993) "Synaptic Integration in an Excitable
Dendritic Tree" (J. Neurophys., Vol 70, Nr. 3, September 1993,
1086-1101). It's on modelling pyramidal neurons in detail. (He used Hines
and Moore's NEURON model.)
Wow! I wish I had that model to incorporate into my Katchalsky nets.
Extremely interesting. EPSPs apparently dissipate rapidly within the
dendritic tree and at different rates depending on type. Some questions for
1. Mel indicates that triggering the active zone around at the axonal
hillock results in an antidromic signal that apparently wipes clean the
accumulating signal in the basal dendrites. Is this the case? He doesn't
discuss the apical dendrites.
2. I'm trying to understand the interaction between Golgi Type I and Type
II neurons at reciprocal synapses. Do these fire in the absence of firing
at the axonal hillock? I assume they do when hit by the antidromic
signal in any case.
3. The soma serves for the most part as a sink for the signals from the
basal dendrites, isolating them from each other. On the other hand, the
apical system operates similarly in some ways to Freemans NCA (my
"activation network"). It tends to kindle and then fire massively. Golgi
Type II neurons are built like pyramidal cells without the axon and
apical system. Does this mean the soma is also an isolating mechanism in
Type II neurons?
4. Is there evidence that the amplitude signal in pyramidal neurons is
contributed by the apical dendrites, while the carrier wave is contributed
by the basal dendrites?
5. Based on anatomy, I would expect the inhibitory cells of the cortex to
synapse on the basal dendrites and soma. Do the cortico-corticals attach
there as well?
Internet: herwin at gmu.edu
Just a dumb engineer working on Katchalsky nets....
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