Neurotrophic Factors?

CROCKETTDP crockettdp at aol.com
Tue Jun 14 20:59:00 EST 1994


In article <2nnikt$t1i at news.delphi.com>, rstetta at news.delphi.com
(RSTETTA at DELPHI.COM) writes:

An additional factor that may play a role is CNTF (ciliary
neurotrophic factor).  Regeneron has been testing CNTF is ALS
patients following some promising results in animals.  However, there
have been a number of problems concerning sideaffects.  See New and
Comments in Science a couple or three weeks ago.

Motoneurons have been shown contain various species of neurotrophic
receptors of the proto-oncogene family trk.   For example, TrkB is
the high-affinity receptor for BDNF and trkC is the high-affinity
receptor for NT-3.  p75 the low-affinity neurotrophin receptor,
capable of binding all of the known neurotrophins.   Its function is
not clear and a number of models have been suggested.   p75 is
expressed in developing motoneurons and motoneurons that have been
axomotomized.  We are presenting data at next year's Soc. Neurosci.
meeting showing a disruption of sensory input also leads to an
up-regulation of p75 in motoneurons.

David P. Crockett
crockett at UMDNJ.EDU



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