Hyperpolarization of Neurons

Rifle River jstream at girch1.med.uth.tmc.edu
Mon May 2 15:12:14 EST 1994


In article <livingst-300494145201 at ts7-06.upenn.edu>,
livingst at pharm.med.upenn.edu (Fred Livingston) wrote:

> The main reason for the inhibition is that if the neuron's conductance is
> wickedly increased to Cl then the neuron is effectively shunted, or clamped
> near the reversal potential of Cl. Make sense?

I never thought of this.  That's a valuable two cents you added.

One question though, why a wicked increase?  Is there such a thing as a
non-wicked increase?  Or, were you merely emphasizing the point that the
permeability for Cl- would have to be very high? 

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