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Postdoctoral position in Cellular Neuroscience

helke at usuhs.ucc.usuhs.nnmc.navy.mil helke at usuhs.ucc.usuhs.nnmc.navy.mil
Fri May 6 16:55:42 EST 1994


This research position, in a medical school neuroscience laboratory, will
focus on the epigenetic influences of transported factors (including
neurotrophins) and depolarizing signals on the regulation of specific
neuropeptides and neurotransmitter enzymes in mature visceral sensory
neurons of the rat nodose ganglion.  These placode-derived visceral
sensory neurons innervate major organ systems of the thorax and
abdomen, and are an integral part of visceral reflexes involved in
maintaining homeostasis.  They contain multiple neuropeptides and
putative neurotransmitters, the content of which is not static.  Studies will
include clarification of the neurochemical identities and plasticity of
nodose ganglion neurons both in situ and in vitro, determination of which
member(s) of the Trk family of neurotrophin receptors is(are) associated
with nodose ganglion neurons and their relationship with specific
neurochemically-defined neurons, the role of NGF, BDNF and/or NT-3
in altering the expression of neuropeptide and neurotransmitter enzyme
mRNAs in mature nodose ganglion neurons in vivo and in vitro.  The
cellular neurobiology techniques to be used include: multiple label in situ
hybridization histochemistry and immunocytochemistry at the single cell
level, cellular autoradiography of retrogradely transported signals, and
primary cultures of mature rat visceral sensory neurons.  

This NIH grant supported position is available in the fall of 1994.  Salary
is commensurate with experience.  Ph.D. in Neuroscience or related
biomedical science and an interest in the regulation of transmitter
expression and transmitter plasticity in adult animals.  Experience with in
situ hybridization histochemistry, primary neuronal tissue culture, and
immunocytochemistry is desired.  

Send a curriculum vita and names of 3-4 references to:

Dr. C.J. Helke
Uniformed Services University of the Health Sciences
Dept. of Pharmacology
4301 Jones Bridge Rd.
Bethesda, MD 20814  USA

phone 301-295-3238; FAX 301-295-3220
bitnet: HELKE at USUHS, internet: helke at usuhs.usuhs.mil

USUHS is located in suburban Washington, D.C. and is close to a wide
variety of cultural, recreational and academic facilities.  The University
was established in 1972 by the U.S. Congress and is located on the
grounds of the National Naval Medical Center in Bethesda.  It is in close
proximity to the National Institutes of Health, National Library of
Medicine, Walter Reed Army Institute of Research, & Armed Forces
Radiobiology Research Institute.  

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