GABA and LTP
Kent Fitzgerald GD 1994
kentfitz at minerva.cis.yale.edu
Wed Oct 5 09:06:52 EST 1994
C. FREDERICK LO (fredlo at welchlink.welch.jhu.edu) wrote:
: In some cases, I believe that inhibition of GABA-A receptors may reduce
: epileptic formation in the hippocampus. Perhaps that's why people use
: picrotoxin in their LTP experiments.
I thought GABA blockers increase the likelihood of seizure activity. I've
heard people who do LTP experiments refer half-seriously to "the fine
line between studying learning and epilepsy."
The reason these drugs are used in slice experiemnts is that they
facilitate the induction of LTP. This phenomenon was one of the earlier
pieces of evidence for a postynpatic mechanism of LTP induction (e.g.
Wigstrom H & Gustafsson B (1983) Nature 301:603).
I was under the impression that the "disinhibited slice" prep was
becoming less popular, and more folks were choosing to do their
Kent Fitzgerald kentfitz at minerva.cis.yale.edu DoD #1367
More information about the Neur-sci