re glutamate and huntingtons

Kanning2 kanning2 at aol.com
Fri Oct 14 17:56:12 EST 1994


In article <37e7p3$ijv at u.cc.utah.edu>, jw0207 at u.cc.utah.edu (john
wagstaff) writes:

Tell me about what an antagonist for glutamate cant be used to stop HD:
Michelle:  Glutamate is the major excitatory transmitter in the brain.  A
chronic dose of an NMDA antagonist may inhibit or completely block
glutamate, but as HD seems to manifest its degeneration in the striatum,
the effects of a pervasive antagonist on the rest of the brain may be
detrimental, especially as glutamate is necessary to inducing LTP in the
hippocampus and comunicating between the thalamus and the cortex.  Also,
MK 801 is the  only antagonist that has been able to pass the blood brain
barrier, so pharmaceutical intervention is difficult.  There is extensive
literature on all of this stuff.  Keep in mind that both the mechanism of
excitotoxicity and the cascade leading to cell death in HD are not known,
although largely hypothesized.  
your undergrad, kanning2.aol



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