Q: chronic vs. subacute treatment

Piotr Wlaz WLAZ at PLUMCS11.UMCS.LUBLIN.PL
Sun Oct 23 13:38:28 EST 1994


I would be satisfied if you could answer my two questions. The first one is
of a general nature: why in pharmacological experiments is 7-14 day-treatment
considered chronic, while in toxicological ones this time period is usually
called subacute. In the latter category of studies 'chronic experiment' is
one lasting for several months.

The second question is more specific. Opioids are thought to work at least in
part through adenosine-related events. The reversal of the analgesic action of
morphine by caffeine or other adenosine antagonists seems to be consistent with
 this hypothesis. However, caffeine has been used for many years in combination
 with typical analgesic drugs like NSADs. Is that a bit of discrepancy?
Does caffeine possess any analgesic activity per se?

Thank you in advance,
Piotr Wlaz



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