Sygen and Spinal Cord Injury

WiseY wisey at
Sun Apr 23 01:44:37 EST 1995

fritzk at (Fred Kinas) writes on 18 Apr 1995 06:29:28 GMT:

I'm not sure if this is the correct newsgroup to post this to, but has any
one have recent information concerning the use of Sygen ( Ganglionic
factor ) for use in post trauma spinal cord injury?

Sygen is the commercial name for a drug containing the monosialic
ganglioside GM1.  It was reported in 1991 by Geisler, et al. to improve
locomotory recovery in patients when the drug was given starting 24-48
hours after injury and continued for several weeks.  The study was a small
one and is now being repeated in a national multicenter trial.  The
results of this trial should be available sometime next year.  The
Geisler, et al references are as follows:
1. Geisler FH, Dorsey FC, Coleman WP (1991).  Recovery of motor function
after spinal-cord injury - a randomized, placebo-controlled trial with
GM-1 ganglioside.  New Engl J Med 324: 1829-38.
2. Geisler FH (1993).  GM-1 ganglioside and motor recovery following human
spinal cord injury.  Journal of Emergency Medicine 1: 49-55.
3. Geisler FH, Dorsey FC, Coleman WP (1992).  GM-1 ganglioside in human
spinal cord injury.  J Neurotrauma 9: S517-S530.

If you need more information on the subject, the following reviews may be

1. Skaper SD, Leon A (1992).  Monosialogangliosides, neuroprotection, and
neuronal repair processes. [Review].  Journal of Neurotrauma 9: S507-16.
2. Rodden FA, Wiegandt H, Bauer BL (1991).  Gangliosides: the relevance of
current research to neurosurgery.  J Neurosurg 74: 606-19.
3. Nobile-Orazio E, Carpo M, Scarlato G (1994).  Gangliosides. Their role
in clinical neurology. [Review].  Drugs 47: 576-85.

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