Spinal Cord Regeneration

WiseY wisey at aol.com
Sun Apr 23 00:54:36 EST 1995


There has been a great deal of progress in the field of spinal cord
regeneration in the past decade.  The senior author of the paper mentioned
in the preceding posting is Martin Schwab at the University of Zurich. 
His laboratory showed in 1988-1990 that there is one or more proteins
present in white matter of the spinal cord, apparently on oligodendroglial
cells, that inhibits growth of neurites.  This finding has stimulated the
field greatly in the direction of studying natural inhibitors of
regeneration in the spinal cord.  In a series of studies starting in 1991,
they have shown that blockade of the inhibitory protein with an antibody
(called IN-1) allowed regeneration in lesioned spinal cord of rats.  In
1994, they showed that a combination of IN-1 and a growth factor called
NT3 produced even better regeneration.  In presentations at recent
meetings, Dr. Schwab and Dr. Bregman have reported functional recovery
associated with such regeneration in rats.  Some of the papers are listed
below:
1. Savio T, Schwab ME (1990).  Lesioned corticospinal tract axons
regenerate in myelin-free rat spinal cord.  Proc Natl Acad Sci (U S A) 87:
4130-3.
2. Schwab ME (1992).  Regeneration of lesioned CNS axons by neutralization
of neurite growth inhibitors: a short review.  J Neurotrauma 9: S219-21.
3. Schnell L, Schwab ME (1990).  Axonal regeneration in the rat spinal
cord produced by an antibody against myelin-associated neurite growth
inhibitors.  Nature 343: 269-72.
4. Schnell L, Schneider R, Kolbeck R, Barde YA, Schwab ME (1994). 
Neurotrophin-3 enhances sprouting of corticospinal tract during
development and after adult spinal cord lesion [see comments].  Nature
367: 170-3.
5. Schwab ME, Caroni P (1988).  Oligodendrocytes and CNS myelin are
nonpermissive substrates for neurite growth and fibroblast spreading in
vitro.  J Neurosci 8: 2381-93.
6. Schwab ME (1990).  Myelin-associated inhibitors of neurite growth.  Exp
Neurol 109: 2-5.

If there is more interest in this subject, I can post more information.

Wise Young, Ph.D., M.D.
NYU Medical Center




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