Spinal Cord Regeneration

x011 at Lehigh.EDU x011 at Lehigh.EDU
Mon Apr 24 08:04:01 EST 1995


In article <3ncq2s$nrv at newsbf02.news.aol.com>, wisey at aol.com (WiseY) writes:
>There has been a great deal of progress in the field of spinal cord
>regeneration in the past decade.  The senior author of the paper mentioned
>in the preceding posting is Martin Schwab at the University of Zurich.
>His laboratory showed in 1988-1990 that there is one or more proteins
>present in white matter of the spinal cord, apparently on oligodendroglial
>cells, that inhibits growth of neurites.  This finding has stimulated the
>field greatly in the direction of studying natural inhibitors of
>regeneration in the spinal cord.  In a series of studies starting in 1991,
>they have shown that blockade of the inhibitory protein with an antibody
>(called IN-1) allowed regeneration in lesioned spinal cord of rats.  In
>1994, they showed that a combination of IN-1 and a growth factor called
>NT3 produced even better regeneration.  In presentations at recent
>meetings, Dr. Schwab and Dr. Bregman have reported functional recovery
>associated with such regeneration in rats.  Some of the papers are listed
>below:
>1. Savio T, Schwab ME (1990).  Lesioned corticospinal tract axons
>regenerate in myelin-free rat spinal cord.  Proc Natl Acad Sci (U S A) 87:
>4130-3.
>2. Schwab ME (1992).  Regeneration of lesioned CNS axons by neutralization
>of neurite growth inhibitors: a short review.  J Neurotrauma 9: S219-21.
>3. Schnell L, Schwab ME (1990).  Axonal regeneration in the rat spinal
>cord produced by an antibody against myelin-associated neurite growth
>inhibitors.  Nature 343: 269-72.
>4. Schnell L, Schneider R, Kolbeck R, Barde YA, Schwab ME (1994).
>Neurotrophin-3 enhances sprouting of corticospinal tract during
>development and after adult spinal cord lesion [see comments].  Nature
>367: 170-3.
>5. Schwab ME, Caroni P (1988).  Oligodendrocytes and CNS myelin are
>nonpermissive substrates for neurite growth and fibroblast spreading in
>vitro.  J Neurosci 8: 2381-93.
>6. Schwab ME (1990).  Myelin-associated inhibitors of neurite growth.  Exp
>Neurol 109: 2-5.
>
>If there is more interest in this subject, I can post more information.
>
>Wise Young, Ph.D., M.D.
>NYU Medical Center
>
>
Yes, post more information.  Ron Blue x011 at lehigh.edu



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