nutrasweet & methanol & conspiracy
ANONYMOUS.USER at Sunderland.AC.UK
Wed Aug 2 08:39:54 EST 1995
Aspartame is the methyl ester of the dipeptide asp-phe. hence on hydrolysis
methanol would be released.
I'm not sure how common methyl esters are in naturally occuring foodstuffs
prehaps some one could let us know.
As for the conspiracy of silence about aspartame side effects i looked it up in
Martindale pharmocopoeia (13 ed) and found the following points which may be
of relevance to the on going 'debate':
even large doses 50 - 100 mg per kg body weight aspartate levels do not rise
glutamate sensetive individuals were origanlly though to endangered by
aspartame, through the similarity between glu and asp though studies
indicated that they were unaffected by its consumption.
in addition methanol toxicity is highly unlikely. ( fatal dose of methanol is
typically 100- 250 ml - merck safety data sheet- and the most common effect of
chronic exposure is visual impairment which can be permenant) interestingly
as a side point apparently individuals with methanol poisening used to be
treated with ethanol to competitively inhibit the formation of formic acid from
the oxidation of methanol. the assumption being that most of the methanol
would be excreted before it could be processed by the alcohol dehydrogenase
enzymes. so if its methanol your worried about have a stiff drinkor two to take
your mind off it.
the risk to pku suffers was also highlighted.
a list of reported side effects was also included in the article these included:
neurological or behavioural symptoms, gastro intestinal symptoms and
hypersensitivity or dermatological symptoms.
it finnishes up with this comment
'available data do not provide evidence for searious widespread health
consequences attendant upon the use of aspartame but it would appear that
certain individuals may have an unusual sensitivity to the product.'
i've a couple of my own points now, appart from my earlier post about why othe
r occupations such as bus and train drivers are not concerned with nutrasweet
induced seizures. also why car insurarance is so easy to get with out declaring
that you dont consume nutrasweet?
short peptides can be very readily absorbed with little or no processing in the
alimentary canal so would an allergic type response be possible to this
dipeptide?- i have in mind something simmilar to the known sensitivites to
seafood , dairy products and the like.
also one of the main uses of nutraswee would appear to be in diet soft drinks,
which are notorious for containing large amounts of artificial colourings,
flavourings and preservatives, some of which are well known for their side
effects on certain susceptable individuals, could this be the actual cause in
these 'nutrasweet seizures' .
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