Agatoxin and P-type voltage-sensitive calcium channels

alex taylor ataylor at superior.carleton.ca
Wed Aug 2 15:55:17 EST 1995


In article <3vnmgk$1v6 at epsilon.qmw.ac.uk>,
Jon Stamford  <j.stamford at lhmc.ac.uk> wrote:
>We are conducting some experiments at the moment looking at the involvement of various types of 
>voltage-sensitive calcium channel on transmitter release. We have already looked at L, N and T 
>channel antagonists. Now we want to block P channels. The only selective antagonist I can find is 
>omega-agatoxin. Unfortunately I cannot find a supplier. Also I understand that the stuff is 
>ferociously expensive. Can anyone give me the address (street or electronic) of a supplier. Also 
>does anyone know if it is irreversible or not. Finally, does anyone know of  alternatives to 
>agatoxin that are selective but cheaper? Any hep would be much appreciated.
>
>Thanks
>
>Jon
>


	Doesn't FTX also block P-channels? I believe Alamone labs will sell
you just about any toxin, but sadly I have no current address. I know they
sell a calcium channel screening kit.



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