Christian Holscher CHOLSCHR at MAIL.TCD.IE
Fri Feb 3 22:03:50 EST 1995

In article <1995Jan30.062021.12020 at>,
flittlej at (Freddie) wrote:

> > The second mechanism is much more heavily studied and involves storing 
> > information within the synapses by adjusting their strength.  This is 
> > thought to occur by increasing the amount of transmitter released from the 
> > presynaptic terminal or by increasing the postsynaptic response to a given 
> > amount of transmitter, or through both mechanisms (see Churchland and 
> > Sejnowski, The Computational Brain).  
> Neuromodulators affect the PSP of a given amount of neurotransmitter. 
> Are neuromodulators know to have an effect on memory?  If
> neuromodulator were administered to a human subject would it not have a
> tremendous impact on memory for the time it is active?

Yes, indeed. In fact, as recent evidence shows, even messengers that were
not believed to play a role in neurons are of importance. There is some
work done about the effect of glycocorticoids, prostaglandins,
leukotriens, and interleukins in learning and memory. They all modulate
memory formation in a positive or negative way. Corticoids for example are
released by neurons, and receptors have been found in neurons as well.
Though the effect of these molecules are very general (induction of enzyme
syntheses etc), they are of importance.


Christian Holscher, PhD
Trinity College Dublin
Dept. Pharmacol. & Therapeutics

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