Botulism exotoxin: mechanism?

DRGPHB drgphb at aol.com
Mon Feb 20 20:19:40 EST 1995


The Clostridial neurotoxin, botulinum, is a zinc endoprotease that cleaves
synaptobrevin (VAMP) in cholinergic neurons.  Synaptobrevin is a vesicle
docking protein; it essential for vesicle fusion with the presynaptic
membrane and neurotransmitter release.  See Gordon Shepherd's Neurobiology
(1994).

I hope this helps.
G. Ballough





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