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Postdoc - Neurosurg/Neurovascular

Charles A. Greer charles_greer at quickmail.cis.yale.edu
Thu Jun 1 13:06:37 EST 1995

Yale University School of Medicine
Section of Neurological Surgery

Laboratory of Microvascular Biology and 
Pediatric Neurosurgical Oncology
Recruitment Announcement for Post-Doctoral Fellowship

Introduction and Research Focus
The Section of Neurological Surgery at Yale University School of Medicine
is actively seeking an individual for appointment as a post-doctoral
fellow in the Laboratory of Microvascular Biology in association with the
Pediatric Neurosurgical Oncology and the Neurovascular Surgery Programs.
This NIH (National Cancer Institute) funded unit is currently carrying out
investigations into the mechanisms of microvascular extravasation as it
relates to peritumoral brain edema and brain tumor cyst formation. Ongoing
studies of tumor-induced angiogenesis have recently been expanded. In
addition, preliminary investigations into the genesis and progression of
non-neoplastic vascular lesions including aneurysms, arteriovenous
malformations, and cavernous angiomas are currently underway. Interested
persons can fully anticipate applying their basic scientific knowledge to
investigations bearing a high degree of clinical relevance.

Applicant Profile
Interested applicants should have recently received a doctoral degree in
cell or molecular biology. Previous work in some aspect of tumor biology
and/or neoangiogenesis would be highly desirable. The applicant should
bring expertise in the fundamental methods of molecular and cell biology.
Equally important would be a willingness to acquire new techniques and
methods as dictated by the evolving focus of the research. Post-doctoral
support will be provided from existing funds for up to two years, with
subsequent support largely derived from applicant-sought funding.

Laboratory Profile
Methodology involving the study of both structural and functional cellular
proteins using fluorescence microscopy, laser scanning confocal
epifluorescence microscopy, immunostaining, receptor studies, in-situ
hybridization, and immunoblotting are desirable. In order to thoroughly
dissect these complex clinical disorders, a multimodal study of tissues
derived from a variety of sources will be required. Specifically, we have
been engaged in the study of both archival paraffinized and fresh tissue
specimens derived from human brain tumors and vascular malformations. In
addition, tissue culture techniques are being used to study endothelial
cells derived from both peripheral macrovessels and brain microvessels.
Finally, a laboratory animal model of abnormal vasculogenesis has been
developed and we fully anticipate its future application to these studies.
This laboratory is currently fully equipped to carry out all of the
investigations discussed herein. Collaborations with several other
established groups in vascular biology and in neuroscience at Yale are
strongly encouraged and fostered. Interested parties should direct their
inquiries as follows.

Equal Opportunity Statement - Yale University is an Equal
Opportunity/Affirmative Action employer. Women and members of minority
groups are encouraged to apply.

Post-Doctoral Fellowship Inquiries

Gregory R. Criscuolo, M.D.                        Issam Awad, M.D., M.Sc.,
Assistant Professor of Surgery (Neurosurgery)                    Professor
of Surgery (Neurosurgery)
Head, Pediatric Neurosurgical Oncology                              Head,
Neurovascular Surgery Program
Director, Laboratory of Microvascular Biology                            
Office - (203) 737-2096
  and Pediatric Neurosurgical Oncology                      Fax - (203) 785-6916
Office - (203) 785-2807                           
Fax - (203) 785-6916

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