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5-HT 1b agonists

Dag Stenberg stenberg at cc.Helsinki.FI
Wed Jun 7 06:27:59 EST 1995

Stephan Anagnostaras (stephan at psych.ucla.edu) wrote:
} <Pine.ULT.3.91j.950606180722.3970A-100000 at stein2.u.washington.edu>, Joshua
} Singer <jhsinger at u.washington.edu> wrote:
} > Does anyone know of specific 5-HT 1b receptor agonists or antagonists? 
} > Any information is appreciated.

} Why don't you just look in the RBI catalog under 5-HT antagonists and
} find selectivity for 1b?

The RBI catalog gives CGS-12066B for an agonist,and gives the reference
Neale &al in Eur.J.Pharmacol. 136,1 (1987).

It does not give any selective antagonists; only pindolol which blocks
both 5-HT1A and 1B. 

So the question still remains partly unanswered.

Dag Stenberg     MD PhD                    stenberg at cc.helsinki.fi
Institute of Biomedicine		   tel: int.+358-0-1918532
Department of Physiology                   fax: int.+358-0-1918681
P.O.Box 9       (Siltavuorenpenger 20 J)   tlx: 1002125 finuh sf
FIN-00014 University of Helsinki,Finland   


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