Memory disorders pt 2

[Carmen N. Nichols]

Many thanks for the postings everyone.  Naturally Alzheimers is the 
obvious choice but was not really what I was looking for.  As far as I 
understand it memory loss is a secondary pathological effect in 
Alzheimers.  What I am really looking for are diseases/syndromes in which 
memory/disfunction is a primary lesion.  In particular I am interested in 
perhaps rare syndromes in which there is evidence for lesions in signal 
transduction mechanisms e.g. cAMP pathway, PKC, IP3 and the like.  If 
there is a down regulation of one of these pathways it may be 
developmentally compensated for but then again it may not be and memory 
disfunction may be a primary effect.  Of course it may be lethal but if 
there is a lesion in a hippocampal specific cyclase (there is evidence for a 
striatal specific cyclase) then there may be a specific disease 
phenotype.  Of course nothing like this may exist and I haven't found 
anything but if such disorders exist then I sure would like to know.

Look foward to hearing from you all

Martin Cann

sarnicol at reading.ac.uk