Cocaine and Alzheimer's

JR Simon jsimon at INDYVAX.IUPUI.EDU
Mon Mar 6 15:13:19 EST 1995


On Mon, 6 Mar 1995, K. Lee Koetzner wrote:

> In a previous article, someone asked,
> > Why not treat Alzheimer's with cocaine, a known dopamine uptake inhibitor?
> which drew a response to the effect of,
> > If there aren't many dopaminergic terminals left, an uptake inhibitor won't h
> ave much transmitter to work with.
> (Sorry about the paraphrases, I accidentally deleted the original posts.)
>  
> It's true that there will be less dopamine release for the drug to "amplify", b
> ut that does not rule the strategy out. In fact, the drug known as Cogentin (tm
> ) or as benztropine (generic) is a dopamine uptake inhibitor which has found so
> me favor as a therapy for Alzheimer's. (Interestingly, the structure of the ben
> ztropine molecule is rather similar to that of cocaine; however, it does not se
> em to have anywhere near the abuse liability.)
> 
> 
I'm not sure, but I think you mean cocaine and Parkinson's not Alzheimer's!




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