Cocaine and Alzheimer's
aguirre_g at mail.med.upenn.edu
Fri Mar 10 22:53:29 EST 1995
In article <17359C5FAS86.KK2543A at american.edu>, KK2543A at american.edu (K.
Lee Koetzner) wrote:
> In a previous article, someone asked,
> > Why not treat Alzheimer's with cocaine, a known dopamine uptake inhibitor?
> which drew a response to the effect of,
> > If there aren't many dopaminergic terminals left, an uptake inhibitor
> ave much transmitter to work with.
> (Sorry about the paraphrases, I accidentally deleted the original posts.)
> It's true that there will be less dopamine release for the drug to
> ut that does not rule the strategy out. In fact, the drug known as
> ) or as benztropine (generic) is a dopamine uptake inhibitor which has
> me favor as a therapy for Alzheimer's. (Interestingly, the structure of
> ztropine molecule is rather similar to that of cocaine; however, it does
> em to have anywhere near the abuse liability.)
Isn't cogentin primarily an anti-cholinergic?
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