Cocaine and Alzheimer's

Geoffrey Aguirre aguirre_g at mail.med.upenn.edu
Fri Mar 10 22:53:29 EST 1995


In article <17359C5FAS86.KK2543A at american.edu>, KK2543A at american.edu (K.
Lee Koetzner) wrote:

> In a previous article, someone asked,
> > Why not treat Alzheimer's with cocaine, a known dopamine uptake inhibitor?
> which drew a response to the effect of,
> > If there aren't many dopaminergic terminals left, an uptake inhibitor
won't h
> ave much transmitter to work with.
> (Sorry about the paraphrases, I accidentally deleted the original posts.)
>  
> It's true that there will be less dopamine release for the drug to
"amplify", b
> ut that does not rule the strategy out. In fact, the drug known as
Cogentin (tm
> ) or as benztropine (generic) is a dopamine uptake inhibitor which has
found so
> me favor as a therapy for Alzheimer's. (Interestingly, the structure of
the ben
> ztropine molecule is rather similar to that of cocaine; however, it does
not se
> em to have anywhere near the abuse liability.)

Isn't cogentin primarily an anti-cholinergic?



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