NSAID'S AND BBB

Kevin Black kevin at npg.wustl.edu
Sat Mar 25 12:27:03 EST 1995


In <3ksmea$27s at cronkite.ocis.temple.edu> jimking at astro.ocis.temple.edu (Country) writes:


>: >I would like to know what non-steroidal anti-inflammatories
>: cross the blood brain barrier.

>: John Friedberg

>There has been work, in fact I've done a little on the subject, 
>concerning the isomeric conversion of certain NSAIDs in the brain.  The 
>one's which I used were flurbiprofen and ketoprofen.  Whether or not 
>they actually enter at the level of the brain or spinal cord is another 
>question.
>-- 
>Live long and play hard! James G. King, Jr. jimking at astro.ocis.temple.edu
>Temple University
>College of Arts and Science

Not a direct answer to your question, but the Medical Letter's issue on
psychiatric side effects of medications notes that some NSAIDs have caused
a sterile meningitis.

Kevin_Black at npg.wustl.edu



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