Ketamine/Xylazine dose for rats?

Michael Vagell Vagell at MSVAX.MSSM.EDU
Wed May 17 17:20:40 EST 1995

What doses of Ketamine & Xylaxine (Rompum) should be administered for
30-45min deep anesthesia during stereotaxic surgery in adult male Long
Evans rats (300-400g)?  I have been using 100mg/Kg Ketamine ip and
15mg/Kg Xylaxine im with good results up until now.  It is the
strangest thing.  We seem to lose  a lot of animals after 5pm (the
animals are kept on a 12:12 reverse light/dark schedule).  Does anyone
else find this temporal hypersensitivity in rodent anesthesia?  Any
suggestions for different doses or using another anesthetic agent? 

Vagell at
Michael Vagell
Department of Cell Biology and Anatomy
Mount Sinai School of Medicine
New York, N.Y.

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