Vasospasm control by sympathetic neurons

Jack Painter jfpco at infi.net
Tue Nov 14 00:16:30 EST 1995


Is anyone familiar with successes of Interleukin-1 or
Cytokines in the regulation or expression of Substance-P
in the sympathetic ganglion?

My wife has Raynaud's secondary to Scleroderma, and numerous
sympathectomies (thoracic and peripheral) are wearing off.
We are hoping that neurologists can treat the cause of
endothelial reaction in sympathetic nerves/arteries, and 
regulate the oxygen tension that maintains vascular tone,
instead of Rheumatologist's efforts to over-dilate, which
may exacerbate the problem rather than cure it.  Secondary
occlusions can and have occurred, but these can be repaired
surgically...tonal control is another matter, and the stripping
of sympathetic nerves either locally or in the ganglion seems
to be temporary - just until the fiberous nerves regenerate.

Any new studies or theories?  Your comments are greatly
appreciated.  Previous consults with UPMC, MUSC, and JHU.

Jack Painter
Virginia
jfpco at infi.net



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