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MITRAGYNINE:A very little known psychotropic molecule from MITRAGYNA SPECIOSA

Keneth Grandchamp grandcha at cmu.unige.ch
Fri Nov 10 10:06:03 EST 1995

Mitragynine,a very little known alkaloid from Mitragyna speciosa.
The mitragyna-tree is a tree growing in Thailand and,locally,known as 
"Cratome".It contains an unusual,poorly-known, psychotropic molecule called 
mitragynine.Mitragynine is reported by local people as having tranquillising 
properties,at low doses,shifting to stimulant properties at higher doses! I 
have experimented with,apparently,low doses consisting of three smoken 
leaves(leaves of the mitragyna-tree are fairly equal in size),in order to 
collect first-hand information about the psychotropic effects of 
mitragynine.What I observed,subjectively,more or less reminds the effects of 
the serotonin re-uptake blockers,such as zimelidine or 
fluvoxamine.Mitragynine,mainly,blocks motivations and induce 
indifference,together with a strong sense of laziness! Everything becomes 
borring to do.It would be interesting to know if mitragynine has serotonin 
re-uptake blocking properties.If someone is working on mitragynine I would be 
happy to know about his or her research.It would also be interesting to 
investigate mitra
gynine and the negative schizophrenic symptoms(blunting of emotions).
Claude Rifat using Ken Grandchamp account

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