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CAPTOPRIL:Induction of Emotionnal Indifference by Captopril

Keneth Grandchamp grandcha at cmu.unige.ch
Fri Nov 10 10:02:04 EST 1995

Captopril:Induction of Emotionnal Indifference by Captopril
Captopril is an angiotensin converting enzyme(ACE)inhibitor which has been 
reported to have "anti-depressant" effects.In fact,the alleged anti-depressant 
effect of captopril and related molecules is a pseudo-anti-depressant effect 
because captopril is,in fact,a potent thymoanesthesiser! A thymoanesthesiser 
is a molecule which induces pharmacological blunting of 
emotions.Thymoanesthesisers induce emotionnal indifference reminiscent of the 
blunting of affect which is seen in the negative forms of schizophr
There are many thymoanesthesisers wrongly classified as "anti-depressants"! 
For instance:
I.The serotonin re-uptake blockers such as 
As psychopharmacologists have only experimented their products on animals and 
others(!)they have misinterpreted thymoanesthesy as an "anti-depressant" 
effect because the patients who are emotionnally anesthesised do not complain 
anymore of being depressed!!! So these people wrongly misinterpret emotionnal 
indifference as an "anti-depressant" effect.This error is similar to the case 
of a person who would suffer from painful hemorhoids and who would stop 
complaining when his doctor would put Xylocaine(an a
nesthesic)on his hemorhoids! A naive doctor may then proclaim that his patient 
is "cured" with Xylocaine as he or she does not complain anymore...The 
situation that we have now with thymoanesthesisers is exactly similar but 
instead of anesthesing physical pain you anesthesise psychological 
pain.Anesthesing psychological pain is,clearly, NOT an anti-depressant effect 
as a true anti-depressant effect should stimulate rewarding emotions and the 
desire to live,despite adverse conditions.A true anti-depressan
t should not substract a part of your personality,as thymoanesthesisers do.
When experimenting with captoptil I noticed that this molecule would induce a 
quite strong indifference to everything,sex included! Captopril can make you 
impotent because it suppresses the DESIRE to engage in copulation.I would be 
interested to know what is the real percentage of people taking ACE inhibitors 
who suffer,afterwards,of impotence?
This impotence can be reversed by yohimbine.
What is interesting with captopril is that it can induce depression if you 
stop the medication rather abruptly.This is a very interesting observation as 
normal thymoanesthesisers do not induce depression when they 
The emotional indifference induced by captopril opens a new avenue of research 
in the field of negative schizophrenia.

Claude Rifat(Claude de Cyrano!)using Ken Grandchamp account

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