I wonder if the expert neuroscientists who read this newsgroup might answer the following:
To what extent would severing the medial forebrain bundle at a position proximate to the
base of the prefrontal cortices produce a similar set of symptoms as that seen in damage
to the ventromedial and/or dorsolateral prefrontal cortices themselves?
Are there animal experiments that have severed this nerve pathway?
The question arises after reading Damasio's description of the two cases in *Descartes'
Error*, Phineas Gage, in which the accidental damage seemingly must have involved the
bundle, and Elliot, who underwent an operation and presumably, the surgery might have
avoided destruction of the bundle.
Peter Webster e-mail: vignes at monaco.mc