GAMMA-OH(Gamma-Hydroxybutyrate):The First Authentic Anti-Depressant.
grandcha at cmu.unige.ch
Fri Oct 27 09:21:59 EST 1995
This article was written by Claude Rifat, using Kenneth Grandchamp's account.
GAMMA-OH(Gamma-Hydroxybutyrate):The First Authentic Anti-Depressant.
Recently,the whole world was brainwashed by Lilly Company with a severe
blitzkrieg propaganda on an allegedly "new" anti-depressant called fluoxetine
or Prozac.Lilly lied when it presented Prozac as being the "first" marketed
anti-depressant of a "new" generation!The first marketed anti-depressant of
this new family of anti-depressants called the "SSRI" was ZIMELIDINE marketed
by Astra,in Europe,as Normud.Zimelidine was followed by INDALPINE in
France(Upstène)and then by FLUVOXAMINE in Holland(Floxyfral)
Only FLUVOXAMINE withstood the test of time as zimelidine and indalpine had
some unwanted side-effects,even though indalpine proved to be a remarkable
molecule for treatment resistant persons.Fluvoxamine was marketed in Europe
perhaps 8 YEARS BEFORE its american equivalent Prozac!Even though it did not
reach the US market because American pharmaceutical companies had nothing to
compete with Fluvoxamine...So Fluvoxamine was blocked to reach the US market
until Americans could develop properly their own SS
RI! This is what american businessmen,usually,call "fairplay".By doing
so,millions of Americans did not benefit of Fluvoxamine and,surely,many lives
could had been saved in America by Fluvoxamine....Alas,these lives WERE NOT
saved because of the greed and unfair practices of the american system towards
novel medications invented elsewhere.Millions of depressed Americans were
denied access to Fluvoxamine, for commercial purposes only.This is a moral
perversion of the ethic of medicine.
The sad irony of this situation is that Fluvoxamine is superior ,in all
For instance,Prozac has some unwanted side-effects which fluvoxamine does not
have.Moreover,fluvoxamine can SUPPRESS the side-effects of Prozac! So why use
Prozac at all? This is due to the fact that Lilly was very successful in
launching a perverse propaganda campaign,superbly ignoring our european
product and its anteriority.
Prozac,frequently,induces insomnia and headaches while it is also slighly
sub-hallucinogenic.Fluvoxamine,on the contrary,promotes sleep and alleviates
insomnia.Also no subhallucinogenic phenomena can be detected.One reason why
Prozac has these side-effects is because Prozac
should,preferentially,indirectly activate serotonin 5-HT2A
receptors.Activation of these receptors is a common effect of the
All the unwanted side-effects of,let say a dose of 4O mgr of Prozac are
abolished by an equipotent dose of IOO mgr of fluvoxamine.
Fluvoxamine also suppresses rapidly moral suffering(the hard-core of
depression)and suicidal ideation while Prozac is slower on onset.
So the big commercial problem for american companies was that fluvoxamine was
invented not in America but in Europe and marketed about 8 years before they
could SELL their own similar products....Moral perversion,as I said,and
Another european anti-depressant of which Americans have no equivalent is
AMINEPTINE(Survector)and,naturally,Amineptine is not marketed in the USA even
though it is a dopaminergic anti-depressant and dopaminergic anti-depressants
are known to be more effective in treatment resistant patients.As Japanese
say:"kaouai so" for american patients,meaning american patients are most
unfortunate(because money always comes before morality in the US).
So we are left with the morally unacceptable fact that America has banned
superior european anti-depressants because the same equivalent products did
not yet exist in America.
This behaviour of the american pharmaceutical companies has been
systematic.For instance a good anti-depressant invented in Italy and called
TRAZODONE was imitated in America afterwards by the creation of
NEFAZODONE(Serzone)in order to get also more money! And another novel
anti-depressant invented in Europe,VILOXAZINE,apparently never reached the US
Now I will come to a fantastic anti-depressant called GAMMA-OH,in France,and
save lots of depressed people if it were marketed to that effect.
GAMMA-OH has never been studied as an anti-depressant because of what is
IMIPRAMINOMIMETIC DOGMA .This dogma states that anti-depressants can only be
found by those pharmacological methods which have been applied to discover
imipramine,the first alleged anti-depressant!Clearly,this dogma is nonsense
and it has hampered research on anti-depressants since more than 30
years,forbidding the discovery of true fast-acting anti-depressants.This dogma
also states that it is not possible to achieve an anti-depressant effect
immediately but that one has to suffer for weeks before start
ing to feel better with medication...
GAMMA-OH(or gamma-hydroxybutyrate,a quite simple molecule with a vast array of
psychotropic properties)has proved that this statement was sheer nonsense.
GAMMA-OH was discovered by a friend of mine(the late Dr.Henri Laborit who
introduced the use of chlorpromazine in psychiatry around I952)in I96I in
France and since that time scientists were unable to discover some rather
extraordinary properties of this molecule on depression,anxiety and
sociability! Why? Because nobody seriously studied the psychotropic effects of
this molecule until I started to do the job.For some years GAMMA-OH was used
as an hypnotic in France but people complained that they did no
t sleep long enough with that and would awake too early in the morning!
GAMMA-OH is a remarkable molecule because it can suppress depressive ideation
and anxiety sometimes within less than 3O minutes.It also seems to be
immediately active on the most severe and treatment resistant forms of
depression.Because of such remarkable properties I used to
call,jokingly,GAMMA-OH "Or Potable",in French,which means "potable gold"!
Indeed a molecule which can block your depression and suicidal
ideas,anxiety,etc,in such an efficient way is as precious as gold because it
can save your lif
GAMMA-OH saved my own life many times when all other anti-depressants
failed.For years I suffered of depressive episodes which did not react to
conventional "anti-depressants".Why? Because,in fact,most anti-depressants(an
anti-depressant is also called a THYMOANALEPTIC.A thymoanaleptic is a molecule
which stimulates mood)are not really "anti-depressants" per se but
THYMOANESTHESISERS.A thymoanesthesiser is a molecule which ANESTHESISES
emotions and which,thus,blunt feelings.For instance,if you give "anti
-depressants" to,let say,two lovers together you will notice that their love
feelings towards one another become anesthesised,blunted...Clearly,a molecule
which blunts rewarding emotions is definitely not an authentic anti-depressant
but,rather,a "mind Xylocaine"(xylocaine is an anesthesiser used for hemorhoids
and all kinds of similar pains!).A thymoanesthesiser takes away a part of your
personality and makes you a bit similar to people suffering from negative
schizophrenia.On the contrary if you admini
ster gamma-hydroxybutyrate to a pair of lovers you will notice that it will
enhance their love feelings because it stimulates sociability.
Prozac and Fluvoxamine and all SSRI are,in fact,thymoanesthesisers not
authentic thymoanaleptics.They block depression by SUPPRESSING or reducing
feelings,euphoric or dysphoric and you become a kind of satisfied zombie! No
more suffering but no more real happiness.On the contrary,AMINEPTINE does not
suppress emotions but it does not intensify them either.So amineptine is an
anti-depressant but still not the ideal thymoanaleptic.
After years of reflexions on depression I realised,one day,that a real
anti-depressant should STIMULATE SOCIABILITY.Why? Because depression
is,basically,a defect of sociability.Depression is a state of LOWERED
SOCIABILITY and when natural sociability is lowered in a human brain(for
instance through competition,etc)then this brain starts to suffer
morally.Experience has shown that when sociability is ENHANCED then depression
vanishes.GAMMA-OH is the first molecule discovered which does just this:it
ATES SOCIABILITY.This is why GAMMA-OH is called a SOCIABILISER.
GAMMA-OH is hypothesised to cure depression by stimulation of brain OXYTOCIN
neurotransmission.Oxytocin is a very important molecule responsible of
sociable states,of the maternal instinct and of all activities related to the
maintainance of life.For instance,oxytocin is involved in sex and orgasm and
orgasm intensity seems directly linked to enhanced oxytocin neurotransmission.
GAMMA-OH suppresses depressed ideation with amazing rapidity.You may feel
uncurable dysphoria with suicidal ideation,anxiety,etc,and think that no
medicine or no one could help you until you try gamma-hydroxybutyrate! After
you may just think how crazy you were and feel how life is beautiful and
deserves to be lived and enjoyed!
Gamma-hydroxybutyrate strongly stimulates the desire to be and to remain alive
despite unfavourable circumstances.No conventional so-called anti-depressant
Gamma-OH is the fastest anti-depressant known and can,often,suppress severe
depressive ideation within just hours while conventional thymoanesthesisers
take WEEKS or MONTHS to alleviate suffering...GAMMA-OH therapy is also very
short:less than a month of treatment is effective,as opposed of months or
years of treatment with other treatments.
How to use Gamma-OH
GAMMA-OH(this is the brand name of this molecule in France)should be used as
Three doses of 2 gr per day on an empty stomach.For instance,2gr in the
morning,then 2gr before eating your first meal,at noon,then the last dose at
around 6 in the evening.
GAMMA-OH should always be associated with CLONAZEPAM(Rivotril)Imgr taken in
the morning.If you suffer from intractable moral pain you will be surprised to
feel that your blocked gratifying emotions come back very,very fast!
GAMMA-OH is a self-limiting medicine,which means that you discover by yourself
when it is time to stop medication.Why? Because GAMMA-OH induces EMOTIONAL
SATIETY and when you are emotionally satiated you do not feel like asking for
more joy as you feel already fed up with happiness!!! Yes,you can be fed up
with happiness!This is why people using GAMMA-OH never become addicted.In
fact,GAMMA-OH is even used to treat alcohol and opiate addicts.
GAMMA-OH gives you a strong DESIRE TO LIVE whatever are the circumstances.This
is why it is the only authentic anti-depressant
available.Gamma-hydroxybutyrate was the first sociabiliser which I discovered
through Henri Laborit.Laborit is well-known in France for his many books on
society.He used to drink GAMMA-OH 3 times a week,which maintained him in an
GAMMA-OH is a so-called Gaba B agonist and a TYROSINE HYDROXYLASE ACTIVATOR.
Many years ago I discovered a second class of Sociabilisers(though less potent
because of a mixed pro-serotoninergic action)called the TRYPTOPHAN HYDROXYLASE
INHIBITORS,such as MDMA(3,4 methylenedioxymethylphenylisopropylamine)or
MDAI(5,6 methylenedioxyaminoindane).The sociabilising actions per se of
GAMMA-OH are similar but GAMMA-OH is more potent and perfectly safe while MDMA
is neurotoxic and cardiotoxic.MDAI is a non-neurotoxic analogue of MDMA.New
analogues of both GAMMA-OH and MDMA have been devise
The sociabilising action of MDMA is related to its indirect blocking of
SEROTONIN neurotransmission in a brain structure called the MEDIAN RAPHE
NUCLEUS.When the Median Raphe Nucleus is inactivated then
sociability,spontaneously,appears.In fact,both GAMMA-OH and MDMA could act at
a common site modulating oxytocinergic neurotransmission.I have now a
hypothesis which could link the effects on sociability of these two
molecules.Basically this hypothesis states that MDMA might be an indirect
lase activator by suppressing the action of serotonin at post-synaptic 5-HT-IA
heteroreceptors,thus enhancing the activity of tyrosine hydroxylase in some
unidentified locus.There exists one molecule, called NAN-I9O ,which could help
in evaluating this hypothesis.GAMMA-OH is a pure sociabiliser while MDMA and
MDMA-mimetics are partial sociabilisers.At low doses of MDMA the sociabilising
action of this substance is masked by a pro-serotoninergic action as MDMA
is,also, a serotonin releaser.This effect of
MDMA produces a psychotropic action similar to the serotoninergic
thymoanesthesisers such as fluvoxamine,prozac,sertraline,etc.At higher dosage
the sociabilising action of MDMA becomes manifest.Subjectively speaking 2.5gr
of GAMMA-OH are equivalent to 2OOmgr of MDMA.
GAMMA-OH might,theoretically,be also effective against the negative symptoms
of schizophrenia but this remains to be tested.
GAMMA-OH can be obtained in France under this name.You get it in vials of
2.5gr to be dissolved in orange juice or milk(Henri Laborit's advice!),as its
taste is not good.
GAMMA-OH should never be mixed with alcohol,opiates or anything else except
benzodiazepines, or Amineptine, or Fluvoxamine.
The recommended dose should NOT be exceeded.If you overdose,you fall into a
hypnotic sleep from which you cannot be awaken for hours.Moreover,it could
promote "petit mal" epilepsy in such overdoses.Anyhow there is no need for
overdosing.If used as prescribed here it is a very safe anti-depressant and
GAMMA-OH is available only on prescription.
Claude de Cyrano
Note:We are living since the, I96O's,in a world of INQUISITION against all
psychotropic molecules which generate some forms of pleasure.This modern
Inquisition started in America as a puritanical expression of american
society to ban pleasure from life.This Inquisition should be fought against as
it has halted the development of scientific research on the mind.3O years of
research have been lost because Americans imposed an INTELLECTUAL EMBARGO on
many research involving the mind.For instance, all rese
arch on the hallucinogens was stopped,thanks to this perverse Inquisition.This
intellectual embargo should be lifted and scientists and laymen should fight
No Inquisition can be accepted in the scientific field.American society has
systematically demonised all psychotropic molecules which can give
pleasure.This is sheer madness and should strongly be opposed.The right to use
our brain in the way we want should be a fundamental right of man and put in
the Declaration of Human Rights.I hope this goal will be achieved in the
future.One of the reason which motivated me to write what you are reading is
that GAMMA-OH has been in use,for knowledgeable people in Eu
rope,for decades.Now it reached the USA,unfortunately,because,as usual,some
INQUISITORS are trying to demonise this very useful molecule.These alleged
pseudo-scientific AYATOLLAHS should be put back in their middle-ages
churchs.In Iran ayatollahs are condemning still sex.In America the american
ayatollahs want,desperately,to control the use of our mind.This is an
untolerable situation.Progress is made through freedom and knowledge,not under
the guidance of any ayattolah.Let us make a grassroot movement a
gainst all these ayatollahs! Ayatollahs and similar Inquisitors should go back
into their dungeons!!! Middle-Age is over.
Gamma-OH in France and North-America
Gamma-oh was devised by Dr.Wermuth,in France,for Dr.Henri Laborit who is the
father of chlorpromazine and modern psychopharmacology.Wermuth created
gamma-hydroxybutyrate in I96I in the search of a GABA analog which
could,readily,penetrate the blood-brain barrier.
Gamma-OH soon went to the market as an hypnotic which could be obtained with
no medical prescription.The French,until I started to study this molecule,were
unable to classify it under any class.For sometimes,it was an hypnotic
inducing a form of sleep very similar to normal sleep,then it became a
pre-anesthesiser,etc.About I5 years ago,I,finally,discovered that Gamma-OH
was,in fact,a molecule to be classified under the novel class of the
Sociabilisers,together with its butyrolactone form which is,readily
,transformed into Gamma-OH in the blood by a non specific lactonase.In
fact,butyrolactone is a pro-drug giving rise to gamma-hydroxybutyric
acid.Gamma-OH has a recognised peripherical oxytocinergic action while its
central oxytocin properties are still to be demonstrated but seem very likely.
Gamma-OH is known in France through the many books of Henri Laborit and his
Laborit always praised the properties of Gamma-OH and,as France is definitely
not a puritanical society bannin pleasure from existence,Gamma-OH has always
been available,even though its stimulates pleasure.Unfortunately for
Noth-Americans,the ayatollahs of the pleasure INQUISITION have struck again
and banned gamma-hydroxybutyrate!
This article was written by Claude Rifat, using Kenneth Grandchamp's account.
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