Unethical practices - drug industry
jkenner at cello.gina.calstate.edu
Fri Sep 1 19:50:32 EST 1995
Sy Fisher <sfisher at utmb.edu> writes:
> That's the name of the game when a company's profits are threatened by
> published research results: try to discredit the studies as "flawed"
> or "bad science" (of course, some studies may indeed be flawed). That's
> what Pfizer was trying to do with our Zoloft vs Prozac study (J Clin
> Psychiatry 1995;56:288-296).
Are you referring to the "Selective Serotonin Reuptake Inhibitor Dose
Titration in the Naturalistic Setting" study?
Oops, nevermind that was elsewhere. Damn... wish I had a library.. heh..
anyways, 2 of the 4 researchers listed on the author line are affiliated
with Lilly directly.... I'd be interested in seeing the affiliations of
Zoloft[sertraline], as a drug, is more specific in its actions on the
serotonin transporter than Prozac [fluoxetine]. While there is indeed a
very real possibility that Prozac might be slightly more effective in
aleviating depression due to its effects on the norepinephrine
transporter, this "observation" doesnt mean Prozac is a better SSRI than
Zoloft, but rather that Prozac isn't even an SSRI to begin with...
Zoloft has been more effective for "non-depression" problems treated with
SSRI drugs from what I have learned chatting with psychiatrists and
cruising the net. Prozac is indeed slightly more effective against
depression, as I have learned via similar channels. This is not of course
hard data, nothing but anecdotes actually, but still worthy of note IMHO.
With regards to Prozac's status as an SSRI, make your own decision:
As mentioned in the original article, these drugs typically have active
metabolites which may be significant. Thus, actual in vivo activity may
be slightly different.
Receptor Affinities for SSRI drugs
(Values normalized to the IC50 for 5-HT reuptake)
[Data Taken from: Internatn-Clin-Psychopharm, 9 suppl 1: 19-26 (1994)]
Clomiprimine Fluoxetine Sertraline Paroxetine Fluvoxamine
(Anafranil) (Prozac) (Zoloft) (Paxil) (Luvox)
SRI: 1 SRI: 1 SRI: 1 SRI: 1 SRI: 1
NARI: 14 NARI: 54 NARI: 840 NARI: 280 NARI: 160
DARI: 2900 DARI: 740 DARI: 250 DARI: 18000 DARI: 11000
D1: 130 D1: 1500 D1: 33000 D1: 52000 D1: >26000
D2: 290 D2: 4700 D2: 130000 D2: 180000 D2: 17000
H1: 36 H1: 470 H1: 53000 H1: 66,000 H1: 2900
ACh: 45 ACh: 445 ACh: 5800 ACh: 720 ACh: 8900
S1A: 1900 S1A: 12000 S1A: >530000 S1A: >340000 S1A: >26000
S2A: 36 S2A: 100 S2A: 45000 S2A: 62000 S2A: 3200
S2C: n/a S2C: 235 S2C: n/a S2C: 69000 S2C: 1800
Alpha1: 40 Alpha1:2000 Alpha1:15000 Alpha1: 66000 Alpha1:1300
Alpha2:1200 Alpha2: 410 Alpha2: 9500 Alpha2:300000 Alpha2: 500
Beta: 15000 Beta: 264 Beta: 74000 Beta: 120000 Beta: 23000
Radioligands used in binding:
D1: SCH23390; D2: Spiperone; 5-HT1A: 5-OH-DPAT;
5-HT2A: Ketanserin; 5-HT2C: Ly278584; Alpha1: Prazosin;
Alpha2: Idazoxan; Beta: Dihydroalprenolol; H1: Mepyramine;
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