d1/d2 agonists and antagonists

Mark Laubach laubach at biogfx.neuro.wfu.edu
Thu Apr 4 16:33:08 EST 1996


rode0008 at gold.tc.umn.edu (Joshua S Rodefer) wrote:

>>i am a brand new reader to this group - and i was wondering if anyone knew
>>off hand of specific d1 and d2 agonists and antagonists.

>(from the TIPS 1995 receptor and ion channel supplement)

>			D1			D2

>	agonists	SKF 38393		N 0437
>						fendoldopam
>	
>	antagonists	SCH 23390		(-) sulpiride
>			SKF 83566		domperidone
>			SCH 39166		YM 091512

>cheers,
>josh rodefer
>unviersity of minnesota


Quinpirole is also a good D1 agonist and raclopride is also a good D2
antagonists.

I've used these drugs in some behavioral / neurophysiol studies and
they have pronounced dose-dependent effects.  Its worth looking into.

Mark Laubach




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