Prions? CJD/BSE Connection...

WB Thomas Thomas.William at HOSPITAL.VET.UTK.EDU
Mon Apr 8 12:30:26 EST 1996


Although parenteral inoculation is the most reliable means of
inducing transmissible spongioforms encephalopathy, other routes
can also cause infection. 

Scrapie, the prototype of transmissible encephalopahties, is thought to 
spread in nature by ingestion. In mice infected by this route, there is 
early replication of the infectious agent in the Peyer's patches 
followed by spread tot he spinal cord, probably via gastrintestinal 
nerves.

see: Kimberlin RH, Walker CA. Pathogenesis of scrapie in mice
after intragastric infection. Virus Res 12:213-220,1989.

WB Thomas DVM




More information about the Neur-sci mailing list