Prions? CJD/BSE Connection...

Paul Bush paul at phy.ucsf.edu
Mon Apr 8 14:26:27 EST 1996


In article <4k3nk7$p1c at gap.cco.caltech.edu>, shaunc at alumnae.caltech.edu (Shaun D. Carstairs) writes:

|> Not true.  CJD can be transmitted through both parenteral and oral routes.
|> Prions are remarkably resistant to most agents, chemical and physical, and
|> are noteworthy for being protease-resistant, which means that they would
|> _not_ be digested in the stomach.

How do they get into the blood from the GI tract as whole proteins? How do they
cross the blood/brain barrier to get into the CNS? Is there some kind of active
transport mechanism operating?

Paul



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