GAMMA-OH(Gamma-Hydroxybutyrate):The First Authentic Anti-Depressant (4)
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As I do not have much time to answer,individually,all questions received concerning
Gamma-OH, you will find here more information about this molecule.New information has
been added,regularly,in this article so as to answer to your questions.
Introduction
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Recently,the whole world was brainwashed by Lilly Company with a severe blitzkrieg
propaganda on an allegedly "new" anti-depressant called fluoxetine or Prozac.Lilly
lied when it presented Prozac as being the "first" marketed anti-depressant of a "new"
generation!The first marketed anti-depressant of this new family of anti-depressants
called the "SSRI" was ZIMELIDINE marketed by Astra,in Europe,as Normud,and developped
in Scandinavia.Zimelidine was followed by INDALPINE in France(Upstène)and then by FLU
VOXAMINE in Holland(Floxyfral).
Only FLUVOXAMINE withstood the test of time as zimelidine and indalpine had some
unwanted side-effects,even though indalpine proved to be a remarkable molecule for
some treatment resistant persons.Fluvoxamine was marketed in Europe perhaps 8 YEARS
BEFORE its american equivalent Prozac!Even though it did not reach the US market
because American pharmaceutical companies could not yet compete with Europeans...So
Fluvoxamine was blocked to reach the US market until Americans could develop properly
their own
SSRI! This is what american businessmen,usually,call "fairplay".By doing so,millions
of Americans did not benefit of Fluvoxamine and,surely,many lives could had been saved
in America by Fluvoxamine....Alas,these lives WERE NOT saved because of the greed and
unfair practices of the american system towards novel medications invented
elsewhere.Millions of depressed Americans were denied access to Fluvoxamine, for
commercial purposes only.This is a moral perversion of the ethic of medicine.
The sad irony of this situation is that Fluvoxamine is superior ,in all respects,to
Prozac!
For instance,Prozac has some unwanted side-effects which fluvoxamine does not
have.Moreover,fluvoxamine can SUPPRESS the side-effects of Prozac! So why use Prozac
at all? This is due to the fact that Lilly was very successful in launching a
blitzkrieg propaganda campaign,superbly ignoring our european product and its
anteriority.Moreover,the idea of developping a specific serotonin reuptake blocker was
a european idea and not an american idea as Americans did not believe in the
anti-depressant effects of
serotonin but favoured noradrenaline...
Prozac,frequently,induces insomnia and headaches while it is also slighly
sub-hallucinogenic.Fluvoxamine,on the contrary,promotes sleep and alleviates
headaches.Also no subhallucinogenic phenomena can be detected.One reason why Prozac
has these side-effects is because Prozac should,preferentially,indirectly activate
serotonin 5-HT2A receptors.Activation of these receptors is a common effect of the
hallucinogens.Normally the TYPICAL SSRIs have anti-hallucinogenic properties,meaning
that they are not effec
tive at 5-HT2A receptors,contrary to fluoxetine which is,thus,an ATYPICAL SSRI.
All the unwanted side-effects of,let say a dose of 4O mgr of Prozac are abolished by
an equipotent dose of IOO mgr of fluvoxamine.
Fluvoxamine also suppresses rapidly moral suffering(the hard-core of depression)and
suicidal ideation while Prozac is slower on onset.
So the big commercial problem for american companies was that fluvoxamine was invented
not in America but in Europe and marketed about 8 years before they could SELL their
own similar products....Moral perversion,as I said,and totally unacceptable.Just
recently was fluvoxamine accepted.
No comments!
What is interesting is that in Switzerland Prozac's name has been changed into
Fluctine,probably for commercial reasons.In addition to
fluvoxamine,citalopram,paroxetine and sertraline are available here.So Swiss people
seem to have been less stupid in front of the blitzkrieg for fluoxetine!
Another very good european anti-depressant of which Americans have no equivalent is
AMINEPTINE(Survector)and,naturally,Amineptine is not marketed in the USA even though
it is a dopaminergic anti-depressant and dopaminergic anti-depressants are known to be
more effective in treatment resistant patients.Why Americans have not yet marketed
dopaminergic anti-depressants remains an enigma.As Japanese say:"kaouaï so" for
american patients,meaning american patients are most unfortunate(because money always
come
s before morality in the US).In fact,the activation of dopamine seems more crucial in
order to obtain a fast anti-depressant effect than modulation of other
neurotransmitters as the function of dopamine in the CNS is to metabolically activate
neuronal systems.Dopamine is an ubiquitous metabolic activator while serotonin
has,most frequently,the opposite action(this is called the Dopamine/Serotonin balance
hypothesis;there is also a Serotonin/Serotonin balance hypothesis.This hypothesis
states that the glo
bal metabolic action of serotonin is the ratio of activation of serotonin receptors
diminishing dopaminergic activity to those serotoninergic receptors which increase
dopamine activity,such as the 5-HT2A receptors).Concerning novel anti-depressants the
French have invented the very first Selective Serotonin reuptake
Accelerator(SSRA):Tianeptine.Tianeptine acts in an opposite way as the SSRI
but,still,instead of inducing depressions cure depressions! In the naive understanding
of serotonin in depression
such a fact cannot be understood...We will explain later on why tianeptine is,in
fact,an anti-depressant and even the FIRST authentic serotoninergic anti-depressant!
So we are left with the morally unacceptable fact that America has banned superior
european anti-depressants because the same equivalent products did not yet exist in
America.
This behaviour of the american pharmaceutical companies has been systematic.For
instance a good anti-depressant invented in Italy and called TRAZODONE was,recently,
imitated in America with the creation of NEFAZODONE(Serzone)in order to get more
money! And another novel anti-depressant invented in Europe,VILOXAZINE(the first
selective noradrenaline reuptake inhibitor),apparently never reached the US
market,etc,etc.
Now I will come to a fantastic anti-depressant called GAMMA-OH(brand name),and which
could save lots of depressed people if it were marketed to that effect.
GAMMA-OH has never been studied as an anti-depressant because of what is called the
IMIPRAMINOMIMETIC DOGMA .This dogma states that anti-depressants can only be found by
those pharmacological methods which have been applied to discover imipramine,the first
alleged anti-depressant!Clearly,this dogma is nonsense and it has hampered research on
anti-depressants since more than 30 years,forbidding the discovery of true fast-acting
anti-depressants.This dogma also states that it is not possible to achieve an
anti-depressant effect immediately but that one has to suffer for weeks before start
ing to feel better with medication...What is funny with this grotesque dogma is that
imipramine was discovered by chance!At that time nobody believed in imipramine except
one lone researcher whose obstinate perserverance was rewarded...
GAMMA-OH(or gamma-hydroxybutyrate,a quite simple molecule with a vast array of
psychotropic properties)has proved that this statement was sheer nonsense.
GAMMA-OH was discovered by a friend of mine(the late Dr.Henri Laborit who introduced
the use of chlorpromazine in psychiatry around I952)in I96I in France and since that
time scientists were unable to discover some rather extraordinary properties of this
molecule on depression,anxiety and sociability! Why? Because nobody seriously studied
the psychotropic effects of this molecule until I started to do the job.This stems
from the fact that most "scientists" are not real scientists or savants but only civi
l servants:they work to earn their food,not to really discover nature's
mysteries.These civil servants(called "fonctionnaires",in French,a simpler word) work
like soldiers in an Army,not like true researchers because they are not authentic
researchers!They have ideas and interests of "fonctionnaires" not of savants...For
some years GAMMA-OH was used as an hypnotic in France but people complained that they
did not sleep long enough with that and would awake too early in the
morning!Then,according to Henri
Laborit,came May I968 and Gamma-OH was considered subversive:it thus became a
medicine only available on prescription.And of course a medicine which can enhance
sociability is,indeed,subversive because sociability does not go well along with
business and merchants!To be a good merchant you need,psychologically,to block your
sociable feelings:you should cease to consider other human beings as human beings but
just as things which can bring you money and power.You have to learn to be
selfish,that is non-s
ociable!
GAMMA-OH is a remarkable molecule because it can suppress depressive ideation and
anxiety sometimes within less than 3O minutes.It also seems to be immediately active
on the most severe and treatment resistant forms of depression.Because of such
remarkable properties I used to call,jokingly,GAMMA-OH "Or Potable",in French,which
means "potable gold"! Indeed a molecule which can block your depression and suicidal
ideas,anxiety,etc,in such an efficient way is as precious as gold because it can save
your lif
e.
GAMMA-OH saved my own life many times when all other anti-depressants failed.For years
I suffered of depressive episodes which did not react to conventional
"anti-depressants".Why? Because,in fact,most anti-depressants(an anti-depressant is
also called a THYMOANALEPTIC.A thymoanaleptic is a molecule which stimulates mood)are
not really "anti-depressants" per se but THYMOANESTHESISERS.A thymoanesthesiser is a
molecule which ANESTHESISES emotions and which,thus,blunt feelings.For instance,if you
give "anti
-depressants" to,let say,two lovers together you will notice that their love feelings
towards one another become anesthesised,blunted...Clearly,a molecule which blunts
rewarding emotions is definitely not an authentic anti-depressant but,rather,a "mind
Xylocaine"(xylocaine is an anesthesiser used for hemorhoids and all kinds of similar
pains!).A thymoanesthesiser takes away a part of your personality and makes you a bit
similar to people suffering from negative schizophrenia.On the contrary if you admini
ster gamma-hydroxybutyrate to a pair of lovers you will notice that it will enhance
their love feelings because it stimulates sociability.
Prozac and Fluvoxamine and all SSRI are,in fact,thymoanesthesisers not authentic
thymoanaleptics.They block depression by SUPPRESSING or reducing feelings,euphoric or
dysphoric and you become a kind of satisfied zombie! Another thymoanesthesiser,which
is not a SSRI,and which blocks quite spectacularly love feelings is MAPROTILINE,a
slightly modified tricyclic.In my opinion,maprotiline is psychotoxic because it can
induce indifference in otherwise normal subjects.No more suffering but no more real
happine
ss.On the contrary,AMINEPTINE does not suppress emotions but it does not intensify
them either.So amineptine is an anti-depressant but still not the ideal
thymoanaleptic.Now we can come back to tianeptine.Why tianeptine is an
anti-depressant?We have seen that serotoninergics alleviate depression by REDUCING
emotions.Enhancing serotonin neurotransmission,in fact,anesthesises emotions.Thus it
is logical that reducing serotonin neurotransmission( in some unknown brain areas
)should STIMULATE the expression
of emotions.This is demonstrated by tianeptine and by some tryptophane hydroxylase
inhibitors such as MDA or MDMA.What is more interesting is that even though MDMA
selectively destroys the axons of the raphé nucleus the behavioural consequences of
that are,apparently,non-existent(But damages can be demonstrated in MDMA treated
persons through Fluvoxamine).Further reducing serotonin neurotransmission in MDMA
subjects having a depressive episode,with tianeptine,can suppress depression in these
people! One
person who had taken MDMA at high doses for 5 years and who became depressed reported
that,under tianeptine,he would feel like under MDMA!!! Of course no normal patient has
ever reported an MDMA-like effect with tianeptine...As tianeptine activates emotions
instead of reducing them TIANEPTINE CAN THUS BE CONSIDERED AS THE FIRST AUTHENTIC
SEROTONINERGIC ANTI-DEPRESSANT.But who knows tianeptine in North-America? Nearly
nobody because the French are very,very bad businessmen not like those of Lilly!
French
can invent good novel products but are not good at propaganda.Lilly invented a
mediocre product but persuaded everybody that their product was the best ever...If the
French had been so clever as Lilly,Amineptine,for instance,would have invaded the
whole world years and years ago,not to speak about tianeptine! The French have
invented many novel anti-depressant but did practically nothing to spread them.Some of
these are:médifoxamine(Clédial),minaprine(Cantor),Viloxazine(Vivalan),not to speak
about aminep
tine and tianeptine! What's more they invented(by chance!)Gamma-OH and never
discovered that this was a very novel anti-depressant! Knowledgeable people just used
Gamma-OH like Champagne or Beaujolais but did nothing more...Gamma-OH stayed for the
elite and the elite was not interested to study the peculiar psychotropic effects of
this molecule!
After years of reflexions on depression I realised,one day,that a real anti-depressant
should STIMULATE SOCIABILITY.Why? Because depression is,basically,a defect of
sociability.Depression is a state of LOWERED SOCIABILITY and when natural sociability
is lowered in a human brain(for instance through competition,etc)then this brain
starts to suffer morally.Experience has shown that when sociability is ENHANCED then
depression vanishes.GAMMA-OH is the first molecule discovered which does just this:it
STIMUL
ATES SOCIABILITY.This is why GAMMA-OH is called a SOCIABILISER.
GAMMA-OH is hypothesised to cure depression by stimulation of brain OXYTOCIN
neurotransmission.Oxytocin is a very important molecule responsible of sociable
states,of the maternal instinct and of all activities related to the maintainance of
life.For instance,oxytocin is involved in sex and orgasm and orgasm intensity seems
directly linked to enhanced oxytocin neurotransmission.
GAMMA-OH suppresses depressed ideation with amazing rapidity.You may feel uncurable
dysphoria with suicidal ideation,anxiety,etc,and think that no medicine or no one
could help you until you try gamma-hydroxybutyrate! After you may just think how crazy
you were and feel how life is beautiful and deserves to be lived and enjoyed!
Gamma-hydroxybutyrate strongly stimulates the desire to be and to remain alive despite
unfavourable circumstances.No conventional so-called anti-depressant does that.
Gamma-OH is the fastest anti-depressant known and can,often,suppress severe depressive
ideation within just hours while conventional thymoanesthesisers take WEEKS or MONTHS
to alleviate suffering...GAMMA-OH therapy is also very short:less than a month of
treatment is effective,as opposed of months or years of treatment with other
treatments.
How to use Gamma-OH
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GAMMA-OH(this is the brand name of this molecule in France,as I said before)should be
used as follows:
Three doses of 2 gr per day on an empty stomach.For instance,2gr in the morning,then
2gr before eating your first meal,at noon,then the last dose at around 6 in the
evening.
GAMMA-OH should always be associated with CLONAZEPAM(Rivotril)Imgr taken in the
morning.If you suffer from intractable moral pain you will be surprised to feel that
your blocked gratifying emotions come back very,very fast!
GAMMA-OH is a self-limiting medicine,which means that you discover by yourself when it
is time to stop medication.Why? Because GAMMA-OH induces EMOTIONAL SATIETY and when
you are emotionally satiated you do not feel like asking for more joy as you feel
already fed up with happiness!!! Yes,you can be fed up with happiness!This is why
people using GAMMA-OH do not become addicted.In fact,GAMMA-OH is even used to treat
alcohol and opiate addicts.
GAMMA-OH gives you a strong DESIRE TO LIVE whatever are the circumstances.This is why
it is the only authentic anti-depressant available.Gamma-hydroxybutyrate was the first
sociabiliser which I discovered through Henri Laborit.Laborit is well-known in France
for his many books on society.He used to drink GAMMA-OH 3 times a week,which
maintained him in an amazing shape! However,Gamma-OH,normally,cannot be taken for a
long period of time continuously as it tends to induce fatigue
and,sometimes,anxiety.So e
motional satiety or fatigue,etc,make Gamma-OH a non-addictive medicine as people
will,spontaneously,stop medication when they feel these phenomena!
GAMMA-OH is a so-called Gaba B agonist and a TYROSINE HYDROXYLASE ACTIVATOR.
At pharmacological doses,it has,recently,been found,in Strasbourg(France),to be a
tryptophan hydroxylase activator.At the normal doses used for depression and anxiety
Gamma-OH has a small regulatory dopaminergic activity:it regularises dopaminergic
activity.Gamma-OH is found,naturally,in the brain together with another more rigid
analog called GAMMA-HYDROXY-TRANS-CROTONATE(G.H.T.C).GHTC is a close analogue of
GAMA-AMINO-TRANS-CROTONATE(G.A.T.C) which is one of the most potent agonist of the
newly discove
red Gaba C receptors.It is not known yet whether Gamma-OH or GHTC bind to these Gaba C
receptors.There are specific receptors to 4-OHB(another name of Gamma-OH!)and GHTC in
the brain.These receptors are called GHB receptors.French scientists have found that
some benzamide neuroleptics bind with high affinity to these receptors.Nobody knows
yet what 4-OHB and GHTC do,exactly,in the brain! They may serve as neuromodulators.The
only rather clear thing we know is that stimulation of these receptors could be
involved in the generation of "petit mal" epilepsy.Gamma-OH can induce,very rarely(and
this is not dose-dependent!)slight subjective effects reminiscent of petit mal
epilepsy.These effects are adequately blocked by CLONAZEPAM and this is the reason why
Gamma-OH should,always,better be absorbed with clonazepam or other
benzodiazepines.Benzodiazepines seem to have a good protective effects against the
eventual minor side-effects of Gamma-OH.For instance,short term use of Gamma-OH is
strongly anxiolytic and
a very effective medication for panic attacks which are reversed within I5 to 2O
minutes(on an empty stomach only).However,if Gamma-OH is taken for weeks it can induce
what looks like a "rebound" anxiety phenomenon.This anxiety manifests itself as plain
anxiety or a panic attack just when the psychotropic effects of Gamma-OH start to
wane.In such cases of anxiety,clonazepam(2mgr),midazolam(I5mgr), triazolam(O.5mgr) or
chlorazépate(Tranxène,25 mgr)should be used.Gamma-OH invariably induces vomiting in pe
ople chronically intoxicated with alcohol or people having liver problems.In
fact,Gamma-OH can be used as a test of liver functioning! However,as Gamma-OH
stimulates dopamine activity it can give rise to nausea and vomiting with very slight
increases in the normal dose range which should NEVER exceed 2.5gr within 6
hours.Italians have used Gamma-OH ,to treat alcoholics and opiates addicts, without
serious side effects.They have been using shorter time interval than what I recommend
and big daily doses wi
th heroin addicts with no apparent serious side-effects.This is in contradiction with
what Americans have reported...So is there,now,an American and a European science???
Why Gamma-OH side-effects are "serious" in North-America and "neglegible" in
Europe(Italy)? Are these differences of opinions related to science OR culture???My
opinion is that demonisation of so and so is strongly entranched in North-American
culture.In North-America things have to be good OR bad,black OR white.Something cannot
be good
and bad at the same time,out there...This is an ayatollah way of thinking:it is
cultural Inquisition.We are more realistic and pragmatic in Europe.Even water can lead
to intoxication if taken in sufficient amount...Words can also intoxicate but words
are far more potent than molecules! Adolf Hitler could intoxicate and make millions of
people hallucinate just with a few words...The words of Hitler were hallucinogenic and
far,far more potent than lysergamide(LSD)! Hitler was a potential emotionnal halluc
inogen,like some mushrooms are potential hallucinogens.But this is a philosophical
discussion which does not have its place here! Just good to know because some
north-american "scientists" are also hallucinogenic and spread hallucinations...The
whole north-american system is strongly hallucinogenic with its insidious commercial
and puritanical flavour.This is another debate...Concerning hallucinogens,Shulgin(a
famous scientist)speculated once that 5-Methoxy-DMT (a hallucinogen!)might lift
rapidly depress
ive ideation.Hallucinogens have not been experimented as anti-depressants yet but some
facts suggest that some might have an action.This remains to be determined.
Many years ago I discovered a second class of Sociabilisers(though less potent because
of a mixed pro-serotoninergic action)called the TRYPTOPHAN HYDROXYLASE INHIBITORS,such
as MDMA(3,4 methylenedioxymethylphenylisopropylamine)or MDAI(5,6
methylenedioxyaminoindane).The sociabilising actions per se of MDMA are similar but
GAMMA-OH is more potent and perfectly safe while MDMA is neurotoxic and
cardiotoxic.MDAI is a non-neurotoxic analogue of MDMA.New analogues of both GAMMA-OH
and MDMA have been invented b
ut not yet tested.
The sociabilising action of MDMA is related to its indirect blocking of SEROTONIN
neurotransmission in a brain structure called the MEDIAN RAPHE NUCLEUS.When the Median
Raphe Nucleus is inactivated then sociability,spontaneously,appears.In fact,both
GAMMA-OH and MDMA could act at a common site modulating oxytocinergic
neurotransmission.I have now a hypothesis which could link the effects on sociability
of these two molecules.Basically this hypothesis states that MDMA might be an indirect
tyrosine hydroxy
lase activator by suppressing the action of serotonin at post-synaptic 5-HT-IA
heteroreceptors,thus enhancing the activity of tyrosine hydroxylase in some
unidentified locus.There exists one molecule, called NAN-I9O ,which could help in
evaluating this hypothesis.GAMMA-OH is a pure sociabiliser while MDMA and
MDMA-mimetics are partial sociabilisers.At low doses of MDMA the sociabilising action
of this substance is masked by a pro-serotoninergic action as MDMA is,also, a
serotonin releaser.This effect of
MDMA produces a psychotropic action similar to the serotoninergic thymoanesthesisers
such as fluvoxamine,citalopram,sertraline,etc.At higher dosage the sociabilising
action of MDMA becomes manifest.Subjectively speaking 2.5gr of GAMMA-OH are equivalent
to 2OOmgr of MDMA.Haloperidol Imgr does not block the sociabilising actions of
Gamma-OH while it blocks the dopaminergic effects of a dose of 2OOmgr of Amineptine,a
dopamine re-uptake blocker.Haloperidol might block the sociabilising effects of
MDMA.This i
s not clear yet.
GAMMA-OH might,theoretically,be also effective against the negative symptoms of
schizophrenia but this remains to be tested.
GAMMA-OH can be obtained in France under this name.It has been produced since its
discovery by the Laboratoire Egic,Amilly,France(telephone:30-67-I6-I6).Now it
is,apparently,produced by another company and this company does not know yet that they
have potential gold in their hands because if Gamma-OH is demonstrated to be the
superior anti-depressant which I claim,then it would throw in the garbage can most of
the antique anti-depressants!You get Gamma-OH in vials of 2.5gr to be dissolved in
orange juice
or milk(Henri Laborit's advice!),as its taste is not good.Gamma-OH boxes are blue in
colour and contain only 6 vials.A box costs about IO swiss francs.Gamma-OH
is,sometimes,very effective against migraines but only for one hour and a half! The
activity of Gamma-OH against migraines is not predictable,like many other medicines
used for that.MDMA is also very effective against migraines but this has not been
studied...
GAMMA-OH should never be mixed with alcohol,opiates,antibiotics, or anything else
except benzodiazepines, Amineptine, or Fluvoxamine.The psychotropic effects of IOOmgr
of fluvoxamine will be suppressed,for about one hour and a half,by a dose of 2.5gr of
Gamma-OH.Amineptine does not seem to modify the psychotropic effects of Gamma-OH while
L-Dopa intensifies the hypnotic effects of this molecule.
The recommended dose of Gamma-OH should NOT be exceeded.If you overdose,you fall into
a hypnotic sleep from which you cannot be awaken for hours.Moreover,it could promote
"petit mal" epilepsy in such overdoses,plus nausea and vomiting.Vomiting is a clear
sign of relative over-dosage of Gamma-OH and is related,apparently,both to the
dopaminergic activity of this molecule and to liver function.Anyhow there is no need
for overdosing.If used as prescribed here it is a very safe anti-depressant and
anti-panic
medication.
GAMMA-OH is available only on prescription.I advise those people who see everything in
term of white or black(this is very entrenched in the psychology of white Anglo-Saxons
protestants) to consider the considerable benefits for suffering people that Gamma-OH
could bring if it is demonstrated to be the superior anti-depressant which I claim
here.Afterwards,more research will,very certainly,lead to refined versions of Gamma-OH
with minimal side-effects.
The demonisation of Gamma-OH in North-America:A New Form of Inquisition
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We are living since the, I96O's,in a world of INQUISITION against all psychotropic
molecules which generate some forms of pleasure.This modern Inquisition started in
America as a puritanical expression of american society to ban pleasure from life.This
Inquisition should be fought against as it has halted the development of scientific
research on the mind.3O years of research have been lost because Americans imposed an
INTELLECTUAL EMBARGO on many research involving the mind.For instance, all research
on the hallucinogens was stopped,thanks to this perverse Inquisition.This intellectual
embargo should be lifted and scientists and laymen should fight for that.
No Inquisition can be accepted in the scientific field.American society has
systematically demonised all psychotropic molecules which can give pleasure.(Even
alcohol was demonised but this demonisation was not successful and was abandonned when
it was noticed that the creation of Al Capone and other similar people was a
consequence of this demonisation!)This is sheer madness and should strongly be
opposed.The right to use our brain in the way we want should be a FUNDAMENTAL RIGHT OF
MAN and put in the De
claration of Human Rights.I hope this goal will be achieved in the future.One of the
reason which motivated me to write what you are reading is that GAMMA-OH has been in
use,for knowledgeable people in Europe,for decades.Now it reached the
USA,unfortunately,because,as usual,some american INQUISITORS are trying to demonise
this very useful molecule.These pseudo-scientific AYATOLLAHS should be put back in
their middle-ages churchs.In Iran,ayatollahs are condemning sex.In America,the
american ayatollahs wan
t,desperately,to control the use of our mind.This is an untolerable situation.Progress
is made through freedom and knowledge,not under the guidance of any ayattolah.Let us
make a grassroot movement against all these ayatollahs! Ayatollahs and similar
Inquisitors should go back into their dungeons!!! Middle-Age is over.The quest for
Freedom is a never-ending quest.It is surprising that you do not need,yet,a
prescription for Champagne,wines and other alcohols in North-America because if
alcohol were judged
by pharmaceutical standards it would have been banned a long time ago...
Gamma-OH in France and North-America
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Gamma-oh was invented by Dr.Wermuth,in France,for Dr.Henri Laborit who is the father
of chlorpromazine and modern psychopharmacology.Wermuth created gamma-hydroxybutyrate
in I96I in the search of a GABA analog which could,readily,penetrate the blood-brain
barrier.
Gamma-OH soon went to the market as an hypnotic which could be obtained with no
medical prescription.The French,until I started to study this molecule,were unable to
classify it under any class.For sometimes,it was an hypnotic inducing a form of sleep
very similar to normal sleep,then it became a pre-anesthesiser,etc.About I5 years
ago,I,finally,discovered that Gamma-OH was,in fact,a molecule to be classified under
the novel class of the Sociabilisers,together with its butyrolactone form which
is,readily
,transformed into Gamma-OH in the blood by a non specific lactonase.In
fact,butyrolactone is a pro-drug giving rise to gamma-hydroxybutyric acid.Gamma-OH has
a recognised peripheric oxytocinergic action while its central oxytocin properties are
still to be demonstrated but seem very likely.
Gamma-OH is known in France through the many books of Henri Laborit and his
conferences!
Laborit always praised the properties of Gamma-OH and,as France is definitely not a
puritanical society banning pleasure from existence,Gamma-OH has always been
available,even though its stimulates pleasure.Laborit always advocated the general use
of Gamma-OH in society,like butter or milk! Why? Because it takes away your
stress,makes you more positive towards life,suppresses selectively,like a kind of
"psychological diode",your painful feelings,stimulates your sociability and makes you
more tender,more
loving,more concerned by others.Also you become keenly aware that you have only one
life and that life should be a quest for happiness.Gamma-OH makes you realise how much
you need others(not something for businessmen and militaries or gangsters!!!) and this
is a highly positive thing.I always knew that when Gamma-OH would arrive in
puritanical North-America it would,one day,be demonised...Unfortunately for
North-Americans,the ayatollahs of the pleasure INQUISITION have struck again and
banned gamma-hydro
xybutyrate!Laborit just died,recently,a few months ago at an old age.Sometimes,he used
to joke that Gamma-OH made him live longer as he would suppress his stress with this
"drinkable gold",in case of need!!! He always said that his two greatest discoveries
were chlorpromazine and Gamma-OH but he never fully realised that Gamma-OH could open
a new era in the management of depression and anxiety.He never fought in order to
promote the study of the psychotropic effects of Gamma-OH,he never discovered that G
amma-OH was the first molecule of a novel class:the Sociabilisers.He just enjoyed
Gamma-OH,with his friends,while conducting other researches.All the people who have
surrounded Laborit have,naturally,more or less been exposed to Gamma-OH! I was lucky
to be one of these people.Gamma-OH is still a crude medicine.It should be properly
studied and better analogs should be invented.The use of sociabilisers may have
tremendous effects on our societies,reducing intra-specific aggression and enhancing
cooperatio
n instead of competition.Gamma-OH is a convivial medicine as it shows you that you
need others to be happy.Long term on and off use seems to make you more immune to
stress and dysphoria,more loving towards people in general,more active in your life as
it stimulates your enthusiasm because you are so aware that life can be a fantastic
thing,everyday.The general use of sociabilisers may be a temporary solution for the
intra-specific aggressivity of the human kind.Can Gamma-OH and novel analogs reduce
wars,
at last? I leave this question opened for your reflexion.
I will summarise,now, the psychotropic profile of Gamma-OH,something which I
have done in a lenghty paper many years ago,in French.
Description of the Psychotropic Effects of Gamma-OH(I985)
------------------------------------------------------------------------------
Gamma-OH have the following properties:
A.It stimulates sociability which means that you feel like communicating with other
people in all ways:emotionnal,intellectual,sexual.And from this communication you feel
a very strong and deep happiness.Why? Because,probably,Gamma-OH inactivates a system
which,normally,controls our base-line level of paranoia.Gamma-OH seems to dissolve
paranoia and induce trust.It would had been very interesting to give Gamma-OH to both
Mr.Bush and Saddam Hussein before they started their silly war!
B.Gamma.OH gives you a strong desire to TOUCH others,physically and psychologically.
C.Communication becomes extremely gratifying as you feel you want to become close to
people,not to isolate yourself.
D.Gamma-OH induces a strong sense of BEAUTY.Everything looks so beautiful,so VIVID,so
enjoyable,so pleasurable,so important,so "deep".
C.The perception of movement is enhanced.
D.Three-dimensional perception is enhanced and vision seems more clear,better than
usual.
