GAMMA-OH:The First real Antidepressant

Claude de Contrecoeur Cyrano at beehive.twics.com
Thu Apr 11 23:33:25 EST 1996





GAMMA-OH(Gamma-Hydroxybutyrate):The First Authentic Anti-Depressant (4)
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As I do not have much time to answer,individually,all questions received concerning 
Gamma-OH, you will find here more information about this molecule.New information has 
been added,regularly,in this article so as to answer to your questions.
Introduction
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Recently,the whole world was brainwashed by Lilly Company with a severe blitzkrieg 
propaganda on an allegedly "new" anti-depressant called fluoxetine or Prozac.Lilly 
lied when it presented Prozac as being the "first" marketed anti-depressant of a "new" 
generation!The first marketed anti-depressant of this new family of anti-depressants 
called the "SSRI" was ZIMELIDINE marketed by Astra,in Europe,as Normud,and developped 
in Scandinavia.Zimelidine was followed by INDALPINE in France(Upstène)and then by FLU
VOXAMINE in Holland(Floxyfral).
Only FLUVOXAMINE withstood the test of time as zimelidine and indalpine had some 
unwanted side-effects,even though indalpine proved to be a remarkable molecule for 
some treatment resistant persons.Fluvoxamine was marketed in Europe perhaps 8 YEARS 
BEFORE its american equivalent Prozac!Even though it did not reach the US market 
because American pharmaceutical companies could not yet compete with Europeans...So 
Fluvoxamine was blocked to reach the US market until Americans could develop properly 
their own 
SSRI! This is what american businessmen,usually,call "fairplay".By doing so,millions 
of Americans did not benefit of Fluvoxamine and,surely,many lives could had been saved 
in America by Fluvoxamine....Alas,these lives WERE NOT saved because of the greed and 
unfair practices of the american system towards novel medications invented 
elsewhere.Millions of depressed Americans were denied access to Fluvoxamine, for 
commercial purposes only.This is a moral perversion of the ethic of medicine.
The sad irony of this situation is that Fluvoxamine is superior ,in all respects,to 
Prozac!
For instance,Prozac has some unwanted side-effects which fluvoxamine does not 
have.Moreover,fluvoxamine can SUPPRESS the side-effects of Prozac! So why use Prozac 
at all? This is due to the fact that Lilly was very successful in launching a 
blitzkrieg propaganda campaign,superbly ignoring our european product and its 
anteriority.Moreover,the idea of developping a specific serotonin reuptake blocker was 
a european idea and not an american idea as Americans did not believe in the 
anti-depressant effects of
 serotonin but favoured noradrenaline...
Prozac,frequently,induces insomnia and headaches while it is also slighly 
sub-hallucinogenic.Fluvoxamine,on the contrary,promotes sleep and alleviates 
headaches.Also no subhallucinogenic phenomena can be detected.One reason why Prozac 
has these side-effects is because Prozac should,preferentially,indirectly activate 
serotonin 5-HT2A receptors.Activation of these receptors is a common effect of the 
hallucinogens.Normally the TYPICAL SSRIs have anti-hallucinogenic properties,meaning 
that they are not effec
tive at 5-HT2A receptors,contrary to fluoxetine which is,thus,an ATYPICAL SSRI.
All the unwanted side-effects of,let say a dose of 4O mgr of Prozac are abolished by 
an equipotent dose of IOO mgr of fluvoxamine.
Fluvoxamine also suppresses rapidly moral suffering(the hard-core of depression)and 
suicidal ideation while Prozac is slower on onset.
So the big commercial problem for american companies was that fluvoxamine was invented 
not in America but in Europe and marketed about 8 years before they could SELL their 
own similar products....Moral perversion,as I said,and totally unacceptable.Just 
recently was fluvoxamine accepted.
No comments!
What is interesting is that in Switzerland Prozac's name has been changed into 
Fluctine,probably for commercial reasons.In addition to 
fluvoxamine,citalopram,paroxetine and sertraline are available here.So Swiss people 
seem to have been less stupid in front of the blitzkrieg for fluoxetine!
Another very good european anti-depressant of which Americans have no equivalent is 
AMINEPTINE(Survector)and,naturally,Amineptine is not marketed in the USA even though 
it is a dopaminergic anti-depressant and dopaminergic anti-depressants are known to be 
more effective in treatment resistant patients.Why Americans have not yet marketed 
dopaminergic anti-depressants remains an enigma.As Japanese say:"kaouaï so" for 
american patients,meaning american patients are most unfortunate(because money always 
come
s before morality in the US).In fact,the activation of dopamine seems more crucial in 
order to obtain a fast anti-depressant effect than modulation of other 
neurotransmitters as the function of dopamine in the CNS is to metabolically activate 
neuronal systems.Dopamine is an ubiquitous metabolic activator while serotonin 
has,most frequently,the opposite action(this is called the Dopamine/Serotonin balance 
hypothesis;there is also a Serotonin/Serotonin balance hypothesis.This hypothesis 
states that the glo
bal metabolic action of serotonin is the ratio of activation of  serotonin receptors 
diminishing dopaminergic activity to those serotoninergic receptors which increase 
dopamine activity,such as the 5-HT2A receptors).Concerning novel anti-depressants the 
French have invented the very first Selective Serotonin reuptake 
Accelerator(SSRA):Tianeptine.Tianeptine acts in an opposite way as the SSRI 
but,still,instead of inducing depressions cure depressions! In the naive understanding 
of serotonin in depression 
such a fact cannot be understood...We will explain later on why tianeptine is,in 
fact,an anti-depressant and even the FIRST authentic serotoninergic anti-depressant!
So we are left with the morally unacceptable fact that America has banned superior 
european anti-depressants because the same equivalent products did not yet exist in 
America.
This behaviour of the american pharmaceutical companies has been systematic.For 
instance a good anti-depressant invented in Italy and called TRAZODONE was,recently, 
imitated in America with the creation of NEFAZODONE(Serzone)in order to get more 
money! And another novel anti-depressant invented in Europe,VILOXAZINE(the first 
selective noradrenaline reuptake inhibitor),apparently never reached the US 
market,etc,etc.
Now I will come to a fantastic anti-depressant called GAMMA-OH(brand name),and which 
could save lots of depressed people if it were marketed to that effect.
GAMMA-OH has never been studied as an anti-depressant because of what is called the 
IMIPRAMINOMIMETIC DOGMA .This dogma states that anti-depressants can only be found by 
those pharmacological methods which have been applied to discover imipramine,the first 
alleged anti-depressant!Clearly,this dogma is nonsense and it has hampered research on 
anti-depressants since more than 30 years,forbidding the discovery of true fast-acting 
anti-depressants.This dogma also states that it is not possible to achieve an 
anti-depressant effect immediately but that one has to suffer for weeks before start
ing to feel better with medication...What is funny with this grotesque dogma is that 
imipramine was discovered by chance!At that time nobody believed in imipramine except 
one lone researcher whose obstinate perserverance was rewarded...
GAMMA-OH(or gamma-hydroxybutyrate,a quite simple molecule with a vast array of 
psychotropic properties)has proved that this statement was sheer nonsense. 
GAMMA-OH was discovered by a friend of mine(the late Dr.Henri Laborit who introduced 
the use of chlorpromazine in psychiatry around I952)in I96I in France and since that 
time scientists were unable to discover some rather extraordinary properties of this 
molecule on depression,anxiety and sociability! Why? Because nobody seriously studied 
the psychotropic effects of this molecule until I started to do the job.This stems 
from the fact that most "scientists" are not real scientists or savants but only civi
l servants:they work to earn their food,not to really discover nature's 
mysteries.These civil servants(called "fonctionnaires",in French,a simpler word) work 
like soldiers in an Army,not like true researchers because they are not authentic 
researchers!They have ideas and interests of "fonctionnaires" not of savants...For 
some years GAMMA-OH was used as an hypnotic in France but people complained that they 
did not sleep long enough with that and would awake too early in the 
morning!Then,according to Henri
 Laborit,came May I968 and Gamma-OH was considered subversive:it thus became a 
medicine only available on prescription.And of course a medicine which can enhance 
sociability is,indeed,subversive because sociability does not go well along with 
business and merchants!To be a good merchant you need,psychologically,to block your 
sociable feelings:you should cease to consider other human beings as human beings but 
just as things which can bring you money and power.You have to learn to be 
selfish,that is non-s
ociable!
GAMMA-OH is a remarkable molecule because it can suppress depressive ideation and 
anxiety sometimes within less than 3O minutes.It also seems to be immediately active 
on the most severe and treatment resistant forms of depression.Because of such 
remarkable properties I used to call,jokingly,GAMMA-OH "Or Potable",in French,which 
means "potable gold"! Indeed a molecule which can block your depression and suicidal 
ideas,anxiety,etc,in such an efficient way is as precious as gold because it can save 
your lif
e.
GAMMA-OH saved my own life many times when all other anti-depressants failed.For years 
I suffered of depressive episodes which did not react to conventional 
"anti-depressants".Why? Because,in fact,most anti-depressants(an anti-depressant is 
also called a THYMOANALEPTIC.A thymoanaleptic is a molecule which stimulates mood)are 
not really "anti-depressants" per se but THYMOANESTHESISERS.A thymoanesthesiser is a 
molecule which ANESTHESISES emotions and which,thus,blunt feelings.For instance,if you 
give "anti
-depressants" to,let say,two lovers together you will notice that their love feelings 
towards one another become anesthesised,blunted...Clearly,a molecule which blunts 
rewarding emotions is definitely not an authentic anti-depressant but,rather,a "mind 
Xylocaine"(xylocaine is an anesthesiser used for hemorhoids and all kinds of similar 
pains!).A thymoanesthesiser takes away a part of your personality and makes you a bit 
similar to people suffering from negative schizophrenia.On the contrary if you admini
ster gamma-hydroxybutyrate to a pair of lovers you will notice that it will enhance 
their love feelings because it stimulates sociability.
Prozac and Fluvoxamine and all SSRI are,in fact,thymoanesthesisers not authentic 
thymoanaleptics.They block depression by SUPPRESSING or reducing feelings,euphoric or 
dysphoric and you become a kind of satisfied zombie! Another thymoanesthesiser,which 
is not a SSRI,and which blocks quite spectacularly love feelings is MAPROTILINE,a 
slightly modified tricyclic.In my opinion,maprotiline is psychotoxic because it can 
induce indifference in otherwise normal subjects.No more suffering but no more real 
happine
ss.On the contrary,AMINEPTINE does not suppress emotions but it does not intensify 
them either.So amineptine is an anti-depressant but still not the ideal 
thymoanaleptic.Now we can come back to tianeptine.Why tianeptine is an 
anti-depressant?We have seen that serotoninergics alleviate depression by REDUCING 
emotions.Enhancing serotonin neurotransmission,in fact,anesthesises emotions.Thus it 
is logical that reducing serotonin neurotransmission( in some unknown brain areas 
)should STIMULATE the expression 
of emotions.This is demonstrated by tianeptine and by some tryptophane hydroxylase 
inhibitors such as MDA or MDMA.What is more interesting is that even though MDMA 
selectively destroys the axons of the raphé nucleus the behavioural consequences of 
that are,apparently,non-existent(But damages can be demonstrated in MDMA treated 
persons through Fluvoxamine).Further reducing serotonin neurotransmission in MDMA 
subjects having a depressive episode,with tianeptine,can suppress depression in these 
people! One 
person who had taken MDMA at high doses for 5 years and who became depressed reported 
that,under tianeptine,he would feel like under MDMA!!! Of course no normal patient has 
ever reported an MDMA-like effect with tianeptine...As tianeptine activates emotions 
instead of reducing them TIANEPTINE CAN THUS BE CONSIDERED AS THE FIRST AUTHENTIC 
SEROTONINERGIC ANTI-DEPRESSANT.But who knows tianeptine in North-America? Nearly 
nobody because the French are very,very bad businessmen not like those of Lilly! 
French 
can invent good novel products but are not good at propaganda.Lilly invented a 
mediocre product but persuaded everybody that their product was the best ever...If the 
French had been so clever as Lilly,Amineptine,for instance,would have invaded the 
whole world years and years ago,not to speak about tianeptine! The French have 
invented many novel anti-depressant but did practically nothing to spread them.Some of 
these are:médifoxamine(Clédial),minaprine(Cantor),Viloxazine(Vivalan),not to speak 
about aminep
tine and tianeptine! What's more they invented(by chance!)Gamma-OH and never 
discovered that this was a very novel anti-depressant! Knowledgeable people just used 
Gamma-OH like Champagne or Beaujolais but did nothing more...Gamma-OH stayed for the 
elite and the elite was not interested to study the peculiar psychotropic effects of 
this molecule! 
After years of reflexions on depression I realised,one day,that a real anti-depressant 
should STIMULATE SOCIABILITY.Why? Because depression is,basically,a defect of 
sociability.Depression is a state of LOWERED SOCIABILITY and when natural sociability 
is lowered in a human brain(for instance through competition,etc)then this brain 
starts to suffer morally.Experience has shown that when sociability is ENHANCED then 
depression vanishes.GAMMA-OH is the first molecule discovered which does just this:it 
STIMUL
ATES SOCIABILITY.This is why GAMMA-OH is called a SOCIABILISER.
GAMMA-OH is hypothesised to cure depression by stimulation of brain OXYTOCIN 
neurotransmission.Oxytocin is a very important molecule responsible of sociable 
states,of the maternal instinct and of all activities related to the maintainance of 
life.For instance,oxytocin is involved in sex and orgasm and orgasm intensity seems 
directly linked to enhanced oxytocin neurotransmission.
GAMMA-OH suppresses depressed ideation with amazing rapidity.You may feel uncurable 
dysphoria with suicidal ideation,anxiety,etc,and think that no medicine or no one 
could help you until you try gamma-hydroxybutyrate! After you may just think how crazy 
you were and feel how life is beautiful and deserves to be lived and enjoyed!
Gamma-hydroxybutyrate strongly stimulates the desire to be and to remain alive despite 
unfavourable circumstances.No conventional so-called anti-depressant does that.
Gamma-OH is the fastest anti-depressant known and can,often,suppress severe depressive 
ideation within just hours while conventional thymoanesthesisers take WEEKS or MONTHS 
to alleviate suffering...GAMMA-OH therapy is also very short:less than a month of 
treatment is effective,as opposed of months or years of treatment with other 
treatments.

How to use Gamma-OH
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GAMMA-OH(this is the brand name of this molecule in France,as I said before)should be 
used as follows:
Three doses of 2 gr per day on an empty stomach.For instance,2gr in the morning,then 
2gr before eating your first meal,at noon,then the last dose at around 6 in the 
evening.
GAMMA-OH should always be associated with CLONAZEPAM(Rivotril)Imgr taken in the 
morning.If you suffer from intractable moral pain you will be surprised to feel that 
your blocked gratifying emotions come back very,very fast!
GAMMA-OH is a self-limiting medicine,which means that you discover by yourself when it 
is time to stop medication.Why? Because GAMMA-OH induces EMOTIONAL SATIETY and when 
you are emotionally satiated you do not feel like asking for more joy as you feel 
already fed up with happiness!!! Yes,you can be fed up with happiness!This is why 
people using GAMMA-OH do not become addicted.In fact,GAMMA-OH is even used to treat 
alcohol and opiate addicts.
GAMMA-OH gives you a strong DESIRE TO LIVE whatever are the circumstances.This is why 
it is the only authentic anti-depressant available.Gamma-hydroxybutyrate was the first 
sociabiliser which I discovered through Henri Laborit.Laborit is well-known in France 
for his many books on society.He used to drink GAMMA-OH 3 times a week,which 
maintained him in an amazing shape! However,Gamma-OH,normally,cannot be taken for a 
long period of time continuously as it tends to induce fatigue 
and,sometimes,anxiety.So e
motional satiety or fatigue,etc,make Gamma-OH a non-addictive medicine as people 
will,spontaneously,stop medication when they feel these phenomena!
GAMMA-OH is a so-called Gaba B agonist and a TYROSINE HYDROXYLASE ACTIVATOR.
At pharmacological doses,it has,recently,been found,in Strasbourg(France),to be a 
tryptophan hydroxylase activator.At the normal doses used for depression and anxiety 
Gamma-OH has a small regulatory dopaminergic activity:it regularises dopaminergic 
activity.Gamma-OH is found,naturally,in the brain together with another more rigid 
analog called GAMMA-HYDROXY-TRANS-CROTONATE(G.H.T.C).GHTC is a close analogue of 
GAMA-AMINO-TRANS-CROTONATE(G.A.T.C) which is one of the most potent agonist of the 
newly discove
red Gaba C receptors.It is not known yet whether Gamma-OH or GHTC bind to these Gaba C 
receptors.There are specific receptors to 4-OHB(another name of Gamma-OH!)and GHTC in 
the brain.These receptors are called GHB receptors.French scientists have found that 
some benzamide neuroleptics bind with high affinity to these receptors.Nobody knows 
yet what 4-OHB and GHTC do,exactly,in the brain! They may serve as neuromodulators.The 
only rather clear thing we know is that stimulation of these receptors could be 
involved in the generation of "petit mal" epilepsy.Gamma-OH can induce,very rarely(and 
this is not dose-dependent!)slight subjective effects reminiscent of petit mal 
epilepsy.These effects are adequately blocked by CLONAZEPAM and this is the reason why 
Gamma-OH should,always,better be absorbed with clonazepam or other 
benzodiazepines.Benzodiazepines seem to have a good protective effects against the 
eventual minor side-effects of Gamma-OH.For instance,short term use of Gamma-OH is 
strongly anxiolytic and
 a very effective medication for panic attacks which are reversed within I5 to 2O 
minutes(on an empty stomach only).However,if Gamma-OH is taken for weeks it can induce 
what looks like a "rebound" anxiety phenomenon.This anxiety manifests itself as plain 
anxiety or a panic attack just when the psychotropic effects of Gamma-OH start to 
wane.In such cases of anxiety,clonazepam(2mgr),midazolam(I5mgr), triazolam(O.5mgr) or 
chlorazépate(Tranxène,25 mgr)should be used.Gamma-OH invariably induces vomiting in pe
ople chronically intoxicated with alcohol or people having liver problems.In 
fact,Gamma-OH can be used as a test of liver functioning! However,as Gamma-OH 
stimulates dopamine activity it can give rise to nausea and vomiting with very slight 
increases in the normal dose range which should NEVER exceed 2.5gr within 6 
hours.Italians have used Gamma-OH ,to treat alcoholics and opiates addicts, without 
serious side effects.They have been using shorter time interval than what I recommend 
and big daily doses wi
th heroin addicts with no apparent serious side-effects.This is in contradiction with 
what Americans have reported...So is there,now,an American and a European science??? 
Why Gamma-OH side-effects are "serious" in North-America and "neglegible" in 
Europe(Italy)? Are these differences of opinions related to science OR culture???My 
opinion is that demonisation of so and so is strongly entranched in North-American 
culture.In North-America things have to be good OR bad,black OR white.Something cannot 
be good
 and bad at the same time,out there...This is an ayatollah way of thinking:it is 
cultural Inquisition.We are more realistic and pragmatic in Europe.Even water can lead 
to intoxication if taken in sufficient amount...Words can also intoxicate but words 
are far more potent than molecules! Adolf Hitler could intoxicate and make millions of 
people hallucinate just with a few words...The words of Hitler were hallucinogenic and 
far,far more potent than lysergamide(LSD)! Hitler was a potential emotionnal halluc
inogen,like some mushrooms are potential hallucinogens.But this is a philosophical 
discussion which does not have its place here! Just good to know because some 
north-american "scientists" are also hallucinogenic and spread hallucinations...The 
whole north-american system is strongly hallucinogenic with its insidious commercial 
and puritanical flavour.This is another debate...Concerning hallucinogens,Shulgin(a 
famous scientist)speculated once that 5-Methoxy-DMT (a hallucinogen!)might lift 
rapidly depress
ive ideation.Hallucinogens have not been experimented as anti-depressants yet but some 
facts suggest that some might have an action.This remains to be determined.
Many years ago I discovered a second class of Sociabilisers(though less potent because 
of a mixed pro-serotoninergic action)called the TRYPTOPHAN HYDROXYLASE INHIBITORS,such 
as MDMA(3,4 methylenedioxymethylphenylisopropylamine)or MDAI(5,6 
methylenedioxyaminoindane).The sociabilising actions per se of MDMA are similar but 
GAMMA-OH is more potent and perfectly safe while MDMA is neurotoxic and 
cardiotoxic.MDAI is a non-neurotoxic analogue of MDMA.New analogues of both GAMMA-OH 
and MDMA have been invented b
ut not yet tested.
The sociabilising action of MDMA is related to its indirect blocking of SEROTONIN 
neurotransmission in a brain structure called the MEDIAN RAPHE NUCLEUS.When the Median 
Raphe Nucleus is inactivated then sociability,spontaneously,appears.In fact,both 
GAMMA-OH and MDMA could act at a common site modulating oxytocinergic 
neurotransmission.I have now a hypothesis which could link the effects on sociability 
of these two molecules.Basically this hypothesis states that MDMA might be an indirect 
tyrosine hydroxy
lase activator by suppressing the action of serotonin at post-synaptic 5-HT-IA 
heteroreceptors,thus enhancing the activity of tyrosine hydroxylase in some 
unidentified locus.There exists one molecule, called NAN-I9O ,which could help in 
evaluating this hypothesis.GAMMA-OH is a pure sociabiliser while MDMA and 
MDMA-mimetics are partial sociabilisers.At low doses of MDMA the sociabilising action 
of this substance is masked by a pro-serotoninergic action as MDMA is,also, a 
serotonin releaser.This effect of 
MDMA produces a psychotropic action similar to the serotoninergic thymoanesthesisers 
such as fluvoxamine,citalopram,sertraline,etc.At higher dosage the sociabilising 
action of MDMA becomes manifest.Subjectively speaking 2.5gr of GAMMA-OH are equivalent 
to 2OOmgr of MDMA.Haloperidol Imgr does not block the sociabilising actions of 
Gamma-OH while it blocks the dopaminergic effects of a dose of 2OOmgr of Amineptine,a 
dopamine re-uptake blocker.Haloperidol might block the sociabilising effects of 
MDMA.This i
s not clear yet.
GAMMA-OH might,theoretically,be also effective against the negative symptoms of 
schizophrenia but this remains to be tested.
GAMMA-OH can be obtained in France under this name.It has been produced since its 
discovery by the Laboratoire Egic,Amilly,France(telephone:30-67-I6-I6).Now it 
is,apparently,produced by another company and this company does not know yet that they 
have potential gold in their hands because if Gamma-OH is demonstrated to be the 
superior anti-depressant which I claim,then it would throw in the garbage can most of 
the antique anti-depressants!You get Gamma-OH in vials of 2.5gr to be dissolved in 
orange juice
 or milk(Henri Laborit's advice!),as its taste is not good.Gamma-OH boxes are blue in 
colour and contain only 6 vials.A box costs about IO swiss francs.Gamma-OH 
is,sometimes,very effective against migraines but only for one hour and a half! The 
activity of Gamma-OH against migraines is not predictable,like many other medicines 
used for that.MDMA is also very effective against migraines but this has not been 
studied...
GAMMA-OH should never be mixed with alcohol,opiates,antibiotics, or anything else 
except benzodiazepines, Amineptine, or Fluvoxamine.The psychotropic effects of IOOmgr 
of fluvoxamine will be suppressed,for about one hour and a half,by a dose of 2.5gr of 
Gamma-OH.Amineptine does not seem to modify the psychotropic effects of Gamma-OH while 
L-Dopa intensifies the hypnotic effects of this molecule.
The recommended dose of Gamma-OH should NOT be exceeded.If you overdose,you fall into 
a hypnotic sleep from which you cannot be awaken for hours.Moreover,it could promote 
"petit mal" epilepsy in such overdoses,plus nausea and vomiting.Vomiting is a clear 
sign of relative over-dosage of Gamma-OH and is related,apparently,both to the 
dopaminergic activity of this molecule and to liver function.Anyhow there is no need 
for overdosing.If used as prescribed here it is a very safe anti-depressant and 
anti-panic
 medication.
GAMMA-OH is available only on prescription.I advise those people who see everything in 
term of white or black(this is very entrenched in the psychology of white Anglo-Saxons 
protestants) to consider the considerable benefits for suffering people that Gamma-OH 
could bring if it is demonstrated to be the superior anti-depressant which I claim 
here.Afterwards,more research will,very certainly,lead to refined versions of Gamma-OH 
with minimal side-effects.


The demonisation of Gamma-OH in North-America:A New Form of Inquisition
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We are living since the, I96O's,in a world of INQUISITION against all psychotropic 
molecules  which generate some forms of pleasure.This modern Inquisition started in  
America as a puritanical expression of american society to ban pleasure from life.This 
Inquisition should be fought against as it has halted the development of scientific 
research on the mind.3O years of research have been lost because Americans imposed an 
INTELLECTUAL EMBARGO on many research involving the mind.For instance, all research 
on the hallucinogens was stopped,thanks to this perverse Inquisition.This intellectual 
embargo should be lifted and scientists and laymen should fight for that.
No Inquisition can be accepted in the scientific field.American society has 
systematically demonised all psychotropic molecules which can give pleasure.(Even 
alcohol was demonised but this demonisation was not successful and was abandonned when 
it was noticed that the creation of Al Capone and other similar people was a 
consequence of this demonisation!)This is sheer madness and should strongly be 
opposed.The right to use our brain in the way we want should be a FUNDAMENTAL RIGHT OF 
MAN and put in the De
claration of Human Rights.I hope this goal will be achieved in the future.One of the 
reason which motivated me to write what you are reading is that GAMMA-OH has been in 
use,for knowledgeable people in Europe,for decades.Now it reached the 
USA,unfortunately,because,as usual,some american INQUISITORS are trying to demonise 
this very useful molecule.These pseudo-scientific AYATOLLAHS should be put back in 
their middle-ages churchs.In Iran,ayatollahs are condemning sex.In America,the 
american ayatollahs wan
t,desperately,to control the use of our mind.This is an untolerable situation.Progress 
is made through freedom and knowledge,not under the guidance of any ayattolah.Let us 
make a grassroot movement against all these ayatollahs! Ayatollahs and similar 
Inquisitors should go back into their dungeons!!! Middle-Age is over.The quest for 
Freedom is a never-ending quest.It is surprising that you do not need,yet,a 
prescription for Champagne,wines and other alcohols in North-America because if 
alcohol were judged
 by pharmaceutical standards it would have been banned a long time ago...

Gamma-OH in France and North-America
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Gamma-oh was invented by Dr.Wermuth,in France,for Dr.Henri Laborit who is the father 
of chlorpromazine and modern psychopharmacology.Wermuth created gamma-hydroxybutyrate 
in I96I in the search of a GABA analog which could,readily,penetrate the blood-brain 
barrier.
Gamma-OH soon went to the market as an hypnotic which could be obtained with no 
medical prescription.The French,until I started to study this molecule,were unable to 
classify it under any class.For sometimes,it was an hypnotic inducing a form of sleep 
very similar to normal sleep,then it became a pre-anesthesiser,etc.About I5 years 
ago,I,finally,discovered that Gamma-OH was,in fact,a molecule to be classified under 
the novel class of the Sociabilisers,together with its butyrolactone form which 
is,readily
,transformed into Gamma-OH in the blood by a non specific lactonase.In 
fact,butyrolactone is a pro-drug giving rise to gamma-hydroxybutyric acid.Gamma-OH has 
a recognised peripheric oxytocinergic action while its central oxytocin properties are 
still to be demonstrated but seem very likely.
Gamma-OH is known in France through the many books of Henri Laborit and his 
conferences!
Laborit always praised the properties of Gamma-OH and,as France is definitely not a 
puritanical society banning pleasure from existence,Gamma-OH has always been 
available,even though its stimulates pleasure.Laborit always advocated the general use 
of Gamma-OH in society,like butter or milk! Why? Because it takes away your 
stress,makes you more positive towards life,suppresses selectively,like a kind of 
"psychological diode",your painful feelings,stimulates your sociability and makes you 
more tender,more 
loving,more concerned by others.Also you become keenly aware that you have only one 
life and that life should be a quest for happiness.Gamma-OH makes you realise how much 
you need others(not something for businessmen and militaries or gangsters!!!) and this 
is a highly positive thing.I always knew that when Gamma-OH would arrive in 
puritanical North-America it would,one day,be demonised...Unfortunately for 
North-Americans,the ayatollahs of the pleasure INQUISITION have struck again and 
banned gamma-hydro
xybutyrate!Laborit just died,recently,a few months ago at an old age.Sometimes,he used 
to joke that Gamma-OH made him live longer as he would suppress his stress with this 
"drinkable gold",in case of need!!! He always said that his two greatest discoveries 
were chlorpromazine and Gamma-OH but he never fully realised that Gamma-OH could open 
a new era in the management of depression and anxiety.He never fought in order to 
promote the study of the psychotropic effects of Gamma-OH,he never discovered that G
amma-OH was the first molecule of a novel class:the Sociabilisers.He just enjoyed 
Gamma-OH,with his friends,while conducting other researches.All the people who have 
surrounded Laborit have,naturally,more or less been exposed to Gamma-OH! I was lucky 
to be one of these people.Gamma-OH is still a crude medicine.It should be properly 
studied and better analogs should be invented.The use of sociabilisers may have 
tremendous effects on our societies,reducing intra-specific aggression and enhancing 
cooperatio
n instead of competition.Gamma-OH is a convivial medicine as it shows you that you 
need others to be happy.Long term on and off use seems to make you more immune to 
stress and dysphoria,more loving towards people in general,more active in your life as 
it stimulates your enthusiasm because you are so aware that life can be a fantastic 
thing,everyday.The general use of sociabilisers may be a temporary solution for the 
intra-specific aggressivity of the human kind.Can Gamma-OH and novel analogs reduce 
wars,
at last? I leave this question opened for your reflexion.
I will summarise,now, the psychotropic profile of Gamma-OH,something which I 
have done in a lenghty paper many years ago,in French.

Description of the Psychotropic Effects of Gamma-OH(I985)
------------------------------------------------------------------------------
Gamma-OH have the following properties:
A.It stimulates sociability which means that you feel like communicating with other 
people in all ways:emotionnal,intellectual,sexual.And from this communication you feel 
a very strong and deep happiness.Why? Because,probably,Gamma-OH inactivates a system 
which,normally,controls our base-line level of paranoia.Gamma-OH seems to dissolve 
paranoia and induce trust.It would had been very interesting to give Gamma-OH to both 
Mr.Bush and Saddam Hussein before they started their silly war!
B.Gamma.OH gives you a strong desire to TOUCH others,physically and psychologically.
C.Communication becomes extremely gratifying as you feel you want to become close to 
people,not to isolate yourself.
D.Gamma-OH induces a strong sense of BEAUTY.Everything looks so beautiful,so VIVID,so 
enjoyable,so pleasurable,so important,so "deep".
C.The perception of movement is enhanced.
D.Three-dimensional perception is enhanced and vision seems more clear,better than 
usual.



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