DETERMINE CARDIAC OUTPUT IN ANIMALS

[JAN CZEKAJEWSKI]

During the last decade, the production of transgenic mice, with 
different gene expression provided a valuable tool for the study 
of genes involved in cardiovascular functions in recipient. In 
small animal, the hemodynamic measurement is very limited because 
of the animal size. The most important and basic cardiovascular 
parameters, considered by physiologists and pharmacologists, are 
cardiac output, blood pressure, heart rate and stroke volume. 
Despite the plethora of instruments currently available for 
studying the above mentioned parameters in laboratory animals, no 
such instrument can measure all four parameters simultaneously. 
We developed a device which measures not only all the above 
mentioned parameters but also measures in wide range of animals 
that is from mice to horses. This procedure is thermodilution and 
is widely accepted by different scientists. If you like to 
receive the description of instruments along with the procedure 
in different animals, please e-mail your street address.

GHOSH