Parkinsons-Pesticides

Chris Hatton hatton at ifn-magdeburg.de
Tue Dec 3 20:32:34 EST 1996


> >I also remember from a not so distant Toxicology lecture, something
> >similiar, so I delved into my notes and Leonard's Fundamentals of
> >Psycopharmacology(1992) and Timbrells "Principals of Biochemical
> >toxicology"(1991)

> In <3293C540.4FA0 at Ifn-magdeburg.de> Christopher Hatton
> <Hatton at Ifn-magdeburg.de> writes: 
> >
> >n-methyl-4-phenyl-pyridinium, is the contaminate and the metabolite
> MPP+
> >is the neurotoxin and destroys dopamine preoducing cells.  Leonard
> >speculates that herbicides may produce the same symptoms.  I myself
> >would go along with that and now I would sugges that metabolites in
> >small concetration would cross blood brain barrier after
> >biotransformation by Cyto. P450's on the endothelia cells. (haven't
> >any proof mind) 

Ann Campbell replied:


> +++++++++++++++++++++OHMYGOD, no proof!!! A thinking person!!>


I've been called many things in my life but never a thinking person,
I'll lurk on the newsgroup but no promises of full scale interaction
as I'm not familiar with the area. 
-- 
I've given my brain to Neuroscience, may as well give my body and soul

also, cos there's bugger all life left in either.

http://www.ifn-magdeburg.de

 Please note that these views are my own and not those of my employer

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